| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 11.81M (20.15%) | -48.03K Decreased by -0.41% | Sep 30, 25 |
| 2 | PRIMECAP Management Company | 10.22M (17.44%) | -456.70K Decreased by -4.47% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 7.17M (12.23%) | 61.69K Increased by +0.86% | Dec 31, 25 |
| 4 | Bvf Inc | 7.13M (12.17%) | 4.39M Increased by +61.59% | Dec 31, 25 |
| 5 | RTW INVESTMENTS, LLC | 6.78M (11.57%) | 556.41K Increased by +8.21% | Dec 31, 25 |
| 6 | State Street Corporation | 4.24M (7.23%) | 908.59K Increased by +21.45% | Mar 31, 24 |
| 7 | State Street Corp | 3.67M (6.27%) | -143.78K Decreased by -3.91% | Sep 30, 25 |
| 8 | EcoR1 Capital, LLC | 3.25M (5.55%) | -2.89M Decreased by -89.01% | Dec 31, 25 |
| 9 | FMR Inc | 2.56M (4.37%) | -868.99K Decreased by -33.91% | Dec 31, 23 |
| 10 | Fidelity Management and Research Company | 2.56M (4.37%) | 2.56M Increased by +100.00% | Dec 31, 23 |
| 11 | TCG Crossover Management, LLC | 2.45M (4.18%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Geode Capital Management, LLC | 1.75M (2.99%) | 24.09K Increased by +1.37% | Dec 31, 25 |
| 13 | T. Rowe Price Associates, Inc. | 1.69M (2.89%) | -2.07M Decreased by -122.06% | Sep 30, 25 |
| 14 | BRAIDWELL LP | 1.66M (2.83%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 15 | Defilade Capital Management, L.P. | 1.41M (2.41%) | 1.41M Increased by +100.00% | Dec 31, 25 |
| 16 | Millennium Management LLC | 1.41M (2.41%) | 593.42K Increased by +41.96% | Sep 30, 24 |
| 17 | T. Rowe Price Investment Management,Inc. | 1.35M (2.31%) | -2.43M Decreased by -179.60% | Dec 31, 23 |
| 18 | Royal Bank of Canada | 1.32M (2.25%) | 1.31M Increased by +99.23% | Jun 30, 25 |
| 19 | Legal & General Group PLC | 1.31M (2.23%) | 35.09K Increased by +2.68% | Dec 31, 25 |
| 20 | Logos Global Management LP | 1.25M (2.13%) | 1.25M Increased by +100.00% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | PRIMECAP Odyssey Aggressive Growth | 6.34M (10.83%) | -43.00K Decreased by -0.68% | Dec 31, 25 |
| 2 | iShares Core S&P Small-Cap ETF | 4.35M (7.42%) | 260.64K Increased by +6.00% | Feb 28, 26 |
| 3 | PRIMECAP Odyssey Growth | 3.14M (5.37%) | -413.70K Decreased by -13.16% | Dec 31, 25 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 2.23M (3.81%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 5 | Vanguard US Total Market Shares ETF | 2.17M (3.70%) | 217.00K Increased by +10.00% | Sep 30, 24 |
| 6 | iShares Russell 2000 ETF | 1.72M (2.93%) | 489.61K Increased by +28.51% | Feb 28, 26 |
| 7 | State Street® SPDR® S&P® Biotech ETF | 1.63M (2.78%) | 9.02K Increased by +0.55% | Feb 28, 26 |
| 8 | US Small-Cap Growth II Equity Comp | 1.44M (2.46%) | -154.25K Decreased by -10.71% | Jun 30, 25 |
| 9 | Fidelity Select Health Care | 1.20M (2.05%) | -192.88K Decreased by -16.07% | Dec 31, 23 |
| 10 | T. Rowe Price New Horizons | 1.15M (1.96%) | -293.56K Decreased by -25.61% | Jul 31, 25 |
| 11 | SPDR® S&P Biotech ETF | 1.10M (1.88%) | 2.46K Increased by +0.22% | Aug 31, 25 |
| 12 | Fidelity Advisor® Health Care I | 1.00M (1.71%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 13 | Vanguard Small Cap Index | 812.17K (1.39%) | 1.70K Increased by +0.21% | Feb 28, 26 |
| 14 | T. Rowe Price Small-Cap Value | 799.16K (1.36%) | -397.20K Decreased by -49.70% | Dec 31, 23 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 782.40K (1.34%) | 10.41K Increased by +1.33% | Feb 28, 26 |
| 16 | Fidelity Advisor Health Care I | 750.00K (1.28%) | -146.00K Decreased by -19.47% | Dec 31, 23 |
| 17 | T. Rowe Price Small-Cap Stock | 749.36K (1.28%) | -1.10K Decreased by -0.15% | Sep 30, 23 |
| 18 | T. Rowe Price US Small-Cap Core Equity | 749.36K (1.28%) | -1.10K Decreased by -0.15% | Sep 30, 23 |
| 19 | Vanguard US Opportunities Ins USD Acc | 730.29K (1.25%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | iShares S&P Small-Cap 600 Value ETF | 698.01K (1.19%) | 359.54K Increased by +51.51% | Feb 28, 26 |