| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LLC | 4.54M (11.75%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Paradigm Biocapital Advisors LP | 4.47M (11.57%) | 257.56K Increased by +5.76% | Dec 31, 25 |
| 3 | UBS Asset Mgmt Americas Inc | 4.36M (11.28%) | 2.98M Increased by +68.42% | Mar 31, 25 |
| 4 | RA Capital Management, LLC | 3.21M (8.29%) | 3.21M Increased by +100.00% | Mar 31, 25 |
| 5 | The Toronto-Dominion Bank | 3.19M (8.25%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 6 | BlackRock Inc | 2.58M (6.68%) | 176.04K Increased by +6.82% | Sep 30, 25 |
| 7 | Morgan Stanley - Brokerage Accounts | 2.53M (6.54%) | 49.98K Increased by +1.98% | Sep 30, 25 |
| 8 | Jefferies Financial Group Inc | 2.20M (5.69%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 9 | Soleus Capital Management, L.P. | 2.19M (5.65%) | 2.19M Increased by +100.00% | Jun 30, 25 |
| 10 | Vestal Point Capital LP | 2.15M (5.57%) | 522.96K Increased by +24.29% | Mar 31, 25 |
| 11 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.74M (4.50%) | 161.54K Increased by +9.29% | Dec 31, 25 |
| 12 | Millennium Management LLC | 1.47M (3.80%) | 874.71K Increased by +59.55% | Sep 30, 25 |
| 13 | SG Americas Securities, LLC | 1.38M (3.56%) | 220.26K Increased by +15.99% | Dec 31, 25 |
| 14 | Nantahala Capital Management, LLC | 1.36M (3.53%) | -8.24K Decreased by -0.60% | Mar 31, 25 |
| 15 | American Century Companies Inc | 1.36M (3.52%) | 1.36M Increased by +100.00% | Dec 31, 25 |
| 16 | UBS Group AG | 1.17M (3.03%) | 250.39K Increased by +21.34% | Mar 31, 25 |
| 17 | MENORA MIVTACHIM HOLDINGS LIMITED | 1.15M (2.98%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 18 | HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1.13M (2.91%) | 1.13M Increased by +100.00% | Dec 31, 25 |
| 19 | JPMorgan Chase & Co | 1.07M (2.77%) | 678.73K Increased by +63.49% | Sep 30, 25 |
| 20 | TANG CAPITAL MANAGEMENT LLC | 1.00M (2.59%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 4.69M (12.14%) | 4.69M Increased by +100.00% | Dec 31, 24 |
| 2 | RTW Biotech Opportunities Ord | 1.36M (3.51%) | 1.36M Increased by +100.00% | Jun 30, 25 |
| 3 | UBS (Lux) Digital Health Equity SB USD | 1.32M (3.41%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 4 | UBS Lux Dgtl Hlth Eq Fd seeding P acc | 1.25M (3.23%) | 0.00 Increased by 0.00% | May 31, 25 |
| 5 | CS (Lux) Digital Health Equity SB USD | 1.20M (3.10%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 6 | iShares Russell 2000 ETF | 901.20K (2.33%) | 901.20K Increased by +100.00% | Feb 28, 26 |
| 7 | American Century Small Cap Growth Inv | 653.04K (1.69%) | 653.04K Increased by +100.00% | Dec 31, 25 |
| 8 | American Century U.S. Small Cap Growth | 653.04K (1.69%) | 653.04K Increased by +100.00% | Dec 31, 25 |
| 9 | Biotech Growth Ord | 582.00K (1.51%) | -209.90K Decreased by -36.07% | Nov 30, 25 |
| 10 | International Biotechnology Ord | 427.15K (1.10%) | -34.85K Decreased by -8.16% | May 31, 25 |
| 11 | Fidelity Small Cap Index | 361.35K (0.93%) | -11.42K Decreased by -3.16% | Dec 31, 25 |
| 12 | Xtrackers S&P 500 Swap ETF 1C | 335.32K (0.87%) | 200.82K Increased by +59.89% | Dec 31, 25 |
| 13 | T. Rowe Price Health Sciences | 298.70K (0.77%) | -160.35K Decreased by -53.68% | Jan 31, 26 |
| 14 | iShares Biotechnology ETF | 290.16K (0.75%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 262.40K (0.68%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 262.40K (0.68%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 17 | iShares Russell 2000 Growth ETF | 252.16K (0.65%) | 119.95K Increased by +47.57% | Feb 28, 26 |
| 18 | MEDICAL BioHealth EUR Acc | 209.84K (0.54%) | 25.14K Increased by +11.98% | Jan 31, 26 |
| 19 | Nuveen Quant Small Cap Equity R6 | 192.15K (0.50%) | -201.06K Decreased by -104.64% | Dec 31, 25 |
| 20 | Fidelity® Small Cap Index | 189.44K (0.49%) | 5.40K Increased by +2.85% | Oct 31, 23 |