| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 13.22M (12.72%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Frazier Life Sciences Management, L.P. | 10.26M (9.87%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | BlackRock Inc | 9.90M (9.53%) | 1.70M Increased by +17.13% | Sep 30, 25 |
| 4 | FMR Inc | 6.50M (6.25%) | 3.20M Increased by +49.23% | Dec 31, 25 |
| 5 | Vanguard Group Inc | 6.43M (6.19%) | 607.67K Increased by +9.44% | Dec 31, 25 |
| 6 | Fairmount Funds Management LLC | 5.16M (4.97%) | -27.07K Decreased by -0.52% | Sep 30, 23 |
| 7 | Vivo Capital, LLC | 5.09M (4.90%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | Marshall Wace Asset Management Ltd | 4.58M (4.41%) | -261.20K Decreased by -5.70% | Dec 31, 25 |
| 9 | Morgan Stanley - Brokerage Accounts | 4.30M (4.14%) | 3.28M Increased by +76.20% | Sep 30, 25 |
| 10 | AllianceBernstein L.P. | 4.29M (4.13%) | 11.10K Increased by +0.26% | Sep 30, 25 |
| 11 | Woodline Partners LP | 4.05M (3.89%) | 1.99M Increased by +49.15% | Jun 30, 25 |
| 12 | Rubric Capital Management LP | 3.77M (3.62%) | -4.77M Decreased by -126.50% | Dec 31, 25 |
| 13 | Wellington Management Company LLP | 3.40M (3.28%) | 150.10K Increased by +4.41% | Dec 31, 25 |
| 14 | MPM Oncology Impact Management LP | 3.29M (3.16%) | -119.87K Decreased by -3.65% | Dec 31, 25 |
| 15 | Viking Global Investors LP | 3.20M (3.08%) | -1.93M Decreased by -60.35% | Dec 31, 25 |
| 16 | Orbimed Advisors, LLC | 3.19M (3.07%) | -117.70K Decreased by -3.69% | Dec 31, 25 |
| 17 | Armistice Capital, LLC | 2.99M (2.88%) | 2.99M Increased by +100.00% | Mar 31, 25 |
| 18 | Octagon Capital Advisors LP | 2.81M (2.71%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 19 | Eventide Asset Management, LLC | 2.62M (2.52%) | 1.24M Increased by +47.32% | Dec 31, 25 |
| 20 | Adage Capital Partners Gp LLC | 2.50M (2.41%) | 2.50M Increased by +100.00% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.42M (3.29%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Eventide Healthcare & Life Sciences I | 2.62M (2.52%) | 1.24M Increased by +47.32% | Dec 31, 25 |
| 3 | Fidelity Select Biotechnology | 2.53M (2.44%) | -46.50K Decreased by -1.84% | Jan 31, 26 |
| 4 | iShares Russell 2000 ETF | 2.22M (2.13%) | 2.22M Increased by +100.00% | Feb 28, 26 |
| 5 | Vanguard US Total Market Shares ETF | 1.78M (1.71%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 6 | MEDICAL BioHealth EUR Acc | 1.39M (1.34%) | 977.24K Increased by +70.21% | Jan 31, 26 |
| 7 | AB Small Cap Growth A | 1.32M (1.27%) | -80.37K Decreased by -6.09% | Jan 31, 26 |
| 8 | Fidelity Small Cap Growth | 1.29M (1.24%) | 1.29M Increased by +100.00% | Dec 31, 25 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 1.14M (1.09%) | 13.04K Increased by +1.15% | Feb 28, 26 |
| 10 | Biotech Growth Ord | 1.03M (0.99%) | 15.80K Increased by +1.54% | Nov 30, 25 |
| 11 | Fidelity Select Health Care | 1.00M (0.96%) | 200.00K Increased by +20.00% | Jan 31, 26 |
| 12 | Fidelity Small Cap Index | 891.33K (0.86%) | 10.65K Increased by +1.19% | Dec 31, 25 |
| 13 | Principal SmallCap Growth I Instl | 806.43K (0.78%) | 806.43K Increased by +100.00% | Jan 31, 26 |
| 14 | iShares Russell 2000 Growth ETF | 759.04K (0.73%) | 759.04K Increased by +100.00% | Feb 28, 26 |
| 15 | Fidelity Small Cap Growth K6 | 643.32K (0.62%) | 643.32K Increased by +100.00% | Dec 31, 25 |
| 16 | iShares Biotechnology ETF | 629.51K (0.61%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 17 | BlackRock Advantage Small Cap Core Instl | 579.25K (0.56%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 18 | Emerald Growth A | 579.25K (0.56%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 19 | Wellington Global Hlthcr Eq USD G Ac | 545.27K (0.52%) | 545.27K Increased by +100.00% | Jan 31, 26 |
| 20 | Fidelity Extended Market Index | 544.93K (0.52%) | -2.26K Decreased by -0.42% | Jan 31, 26 |