| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Farallon Capital Management, L.L.C. | 13.06M (19.25%) | 2.30M Increased by +17.64% | Dec 31, 25 |
| 2 | TCG Crossover Management, LLC | 12.76M (18.81%) | 4.23M Increased by +33.11% | Dec 31, 25 |
| 3 | Boxer Capital Management, LLC | 10.88M (16.03%) | 1.10M Increased by +10.16% | Dec 31, 25 |
| 4 | EcoR1 Capital, LLC | 10.63M (15.67%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 5 | Adage Capital Partners Gp LLC | 10.61M (15.64%) | 8.10M Increased by +76.33% | Dec 31, 25 |
| 6 | Woodline Partners LP | 10.07M (14.85%) | 4.04M Increased by +40.13% | Dec 31, 25 |
| 7 | Boxer Capital LLC | 8.20M (12.08%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 8 | Siren, L.L.C. | 8.17M (12.04%) | 2.28M Increased by +27.95% | Dec 31, 25 |
| 9 | TRV GP IV, LLC | 7.87M (11.61%) | -5.99M Decreased by -76.06% | Dec 31, 25 |
| 10 | Nextech Invest, Ltd. | 7.27M (10.71%) | 1.73M Increased by +23.84% | Dec 31, 25 |
| 11 | Vanguard Group Inc | 6.75M (9.95%) | 1.70M Increased by +25.17% | Dec 31, 25 |
| 12 | BlackRock Inc | 5.65M (8.32%) | 183.65K Increased by +3.25% | Sep 30, 25 |
| 13 | Nextech Invest AG | 5.53M (8.16%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 14 | Balyasny Asset Management LLC | 5.28M (7.78%) | 1.81M Increased by +34.22% | Dec 31, 25 |
| 15 | Southpoint Capital Advisors LP | 5.00M (7.37%) | -276.70K Decreased by -5.53% | Sep 30, 24 |
| 16 | The Goldman Sachs Group Inc | 4.94M (7.29%) | 3.43M Increased by +69.46% | Dec 31, 25 |
| 17 | Logos Global Management LP | 4.20M (6.19%) | 3.25M Increased by +77.38% | Dec 31, 25 |
| 18 | Bellevue Group AG | 3.93M (5.79%) | 3.93M Increased by +100.00% | Dec 31, 25 |
| 19 | Caligan Partners LP | 3.73M (5.50%) | 3.73M Increased by +100.00% | Dec 31, 25 |
| 20 | Nantahala Capital Management, LLC | 3.57M (5.27%) | 1.76M Increased by +49.34% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 3.91M (5.77%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 3.80M (5.60%) | 20.92K Increased by +0.55% | Feb 28, 26 |
| 3 | iShares Russell 2000 ETF | 2.57M (3.80%) | 1.68M Increased by +65.32% | Feb 28, 26 |
| 4 | Fidelity Growth Compy Commingled Pl S | 2.42M (3.56%) | 712.74K Increased by +29.51% | Oct 31, 24 |
| 5 | Fidelity Growth Compy Commingled Pl O | 1.69M (2.50%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 6 | T. Rowe Price Small-Cap Value | 1.54M (2.27%) | -117.06K Decreased by -7.59% | Jul 31, 25 |
| 7 | Fidelity Growth Company Fund | 1.53M (2.26%) | 543.72K Increased by +35.45% | Oct 31, 24 |
| 8 | Fidelity® Small Cap Growth | 1.26M (1.86%) | -1.53K Decreased by -0.12% | Oct 31, 23 |
| 9 | FIAM Small Cap Core CIT Cl B | 1.26M (1.86%) | -29.81K Decreased by -2.37% | Dec 31, 25 |
| 10 | Fidelity Small Cap Growth | 1.25M (1.85%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 11 | T. Rowe Price Small-Cap Stock | 1.19M (1.75%) | 199.50K Increased by +16.82% | Sep 30, 24 |
| 12 | T. Rowe Price US Small-Cap Core Equity | 1.19M (1.75%) | 277.63K Increased by +23.40% | Sep 30, 24 |
| 13 | SPDR® S&P Biotech ETF | 1.12M (1.66%) | 16.00K Increased by +1.42% | Nov 30, 24 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 1.08M (1.59%) | 11.71K Increased by +1.09% | Feb 28, 26 |
| 15 | Fidelity Small Cap Index | 1.04M (1.54%) | 317.32K Increased by +30.43% | Dec 31, 25 |
| 16 | Fidelity® Growth Company | 1.02M (1.50%) | 52.20K Increased by +5.12% | Nov 30, 23 |
| 17 | T. Rowe Price U.S. SC Value Eq Tr-D | 971.86K (1.43%) | 4.71K Increased by +0.48% | Jun 30, 25 |
| 18 | T. Rowe Price U.S. SC Value Eq Tr-Z | 967.15K (1.43%) | 1.56K Increased by +0.16% | Mar 31, 25 |
| 19 | iShares Russell 2000 Value ETF | 913.26K (1.35%) | 454.09K Increased by +49.72% | Feb 28, 26 |
| 20 | Franklin Biotechnology Discv A(acc)USD | 841.05K (1.24%) | 0.00 Increased by 0.00% | Dec 31, 25 |