| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 21.30M (15.11%) | -512.88K Decreased by -2.41% | Sep 30, 25 |
| 2 | Vanguard Group Inc | 15.84M (11.24%) | 319.70K Increased by +2.02% | Dec 31, 25 |
| 3 | State Street Corp | 8.10M (5.75%) | 482.38K Increased by +5.95% | Sep 30, 25 |
| 4 | State Street Corporation | 7.80M (5.53%) | -456.99K Decreased by -5.86% | Mar 31, 24 |
| 5 | Darwin Global Management, Ltd. | 4.05M (2.87%) | 4.05M Increased by +100.00% | Dec 31, 23 |
| 6 | ClearBridge Advisors, LLC | 3.45M (2.45%) | -1.20M Decreased by -34.70% | Dec 31, 25 |
| 7 | Geode Capital Management, LLC | 3.40M (2.41%) | -40.05K Decreased by -1.18% | Dec 31, 25 |
| 8 | Soleus Capital Management, L.P. | 3.14M (2.23%) | -705.42K Decreased by -22.47% | Dec 31, 25 |
| 9 | Woodline Partners LP | 2.57M (1.82%) | 1.15M Increased by +44.66% | Sep 30, 24 |
| 10 | Opaleye Management Inc | 2.26M (1.60%) | -20.00K Decreased by -0.88% | Dec 31, 24 |
| 11 | Paradigm Biocapital Advisors LP | 2.17M (1.54%) | -1.45M Decreased by -66.67% | Dec 31, 23 |
| 12 | Marshall Wace Asset Management Ltd | 2.05M (1.46%) | 2.05M Increased by +100.00% | Jun 30, 24 |
| 13 | Congress Asset Management Company, LLP | 1.92M (1.36%) | 1.92M Increased by +100.00% | Dec 31, 25 |
| 14 | Sofinnova Ventures | 1.86M (1.32%) | -123.69K Decreased by -6.65% | Jun 30, 24 |
| 15 | Nuveen Asset Management, LLC | 1.80M (1.28%) | -232.34K Decreased by -12.91% | Dec 31, 24 |
| 16 | Deep Track Capital, LP | 1.73M (1.22%) | -1.15M Decreased by -66.38% | Sep 30, 24 |
| 17 | Bank of America Corp | 1.70M (1.20%) | -384.52K Decreased by -22.65% | Sep 30, 24 |
| 18 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1.61M (1.14%) | 958.95K Increased by +59.47% | Sep 30, 23 |
| 19 | Hood River Capital Management LLC | 1.58M (1.12%) | 28.45K Increased by +1.80% | Dec 31, 25 |
| 20 | Goldman Sachs Group Inc | 1.57M (1.11%) | -349.51K Decreased by -22.26% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | iShares Core S&P Small-Cap ETF | 8.24M (5.84%) | 8.24M Increased by +100.00% | Feb 28, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 4.79M (3.40%) | 9.10K Increased by +0.19% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 4.36M (3.10%) | 3.80K Increased by +0.09% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 3.53M (2.50%) | 652.79K Increased by +18.50% | Feb 28, 26 |
| 5 | Vanguard Small Cap Index | 3.43M (2.43%) | 10.41K Increased by +0.30% | Feb 28, 26 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 3.18M (2.26%) | 17.54K Increased by +0.55% | Feb 28, 26 |
| 7 | Vanguard Health Care Inv | 3.07M (2.18%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 8 | SPDR® S&P Biotech ETF | 2.30M (1.63%) | 5.12K Increased by +0.22% | Aug 31, 25 |
| 9 | Vanguard Small Cap Growth Index Inv | 1.90M (1.35%) | 2.99K Increased by +0.16% | Feb 28, 26 |
| 10 | Pictet Biotech | 1.79M (1.27%) | 1.79M Increased by +100.00% | Mar 31, 24 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 1.48M (1.05%) | 12.96K Increased by +0.88% | Feb 28, 26 |
| 12 | Fidelity Small Cap Index | 1.42M (1.01%) | -42.85K Decreased by -3.01% | Dec 31, 25 |
| 13 | Fidelity® Small Cap Index | 1.32M (0.94%) | 35.93K Increased by +2.72% | Oct 31, 23 |
| 14 | Vanguard Explorer Inv | 1.30M (0.92%) | 139.62K Increased by +10.71% | Dec 31, 25 |
| 15 | State Street SPDR Port S&P 600 Sm CpETF | 1.26M (0.90%) | 3.49K Increased by +0.28% | Feb 27, 26 |
| 16 | Congress Small Cap Growth Institutional | 1.22M (0.87%) | 60.00K Increased by +4.92% | Feb 28, 26 |
| 17 | iShares Russell 2000 Growth ETF | 1.21M (0.86%) | 39.18K Increased by +3.23% | Feb 28, 26 |
| 18 | SPDR® Portfolio S&P 600™ Sm Cap ETF | 1.20M (0.85%) | 14.39K Increased by +1.20% | Aug 29, 25 |
| 19 | iShares S&P Small-Cap 600 Growth ETF | 1.16M (0.82%) | 1.16M Increased by +100.00% | Feb 28, 26 |
| 20 | Fidelity® Select Biotechnology | 1.16M (0.82%) | 37.16K Increased by +3.21% | Nov 30, 23 |