| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Essex Woodlands Health Ventures | 7.71M (39.87%) | 3.60M Increased by +46.72% | Dec 31, 25 |
| 2 | Nantahala Capital Management, LLC | 5.11M (26.41%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | First Light Asset Management, LLC | 2.75M (14.23%) | 199.39K Increased by +7.24% | Mar 31, 24 |
| 4 | SILVERARC CAPITAL MANAGEMENT, LLC | 2.65M (13.68%) | -135.41K Decreased by -5.11% | Dec 31, 25 |
| 5 | Stonepine Capital Management Llc | 2.35M (12.15%) | 196.51K Increased by +8.36% | Dec 31, 25 |
| 6 | Orbimed Advisors, LLC | 2.16M (11.17%) | -296.36K Decreased by -13.71% | Sep 30, 24 |
| 7 | Vanguard Group Inc | 1.83M (9.46%) | 30.67K Increased by +1.68% | Dec 31, 25 |
| 8 | Dafna Capital Management LLC | 1.44M (7.45%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | AIGH Capital Management, LLC | 1.42M (7.32%) | -1.25M Decreased by -88.01% | Mar 31, 25 |
| 10 | Perkins Capital Management Inc | 1.40M (7.22%) | 563.49K Increased by +40.32% | Dec 31, 25 |
| 11 | Royce & Associates, LP | 1.00M (5.17%) | 1.00M Increased by +100.00% | Dec 31, 24 |
| 12 | Pentwater Capital Management LP | 815.00K (4.21%) | -183.75K Decreased by -22.55% | Jun 30, 25 |
| 13 | Citigroup Inc | 750.00K (3.88%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 14 | Opaleye Management Inc | 750.00K (3.88%) | -830.00K Decreased by -110.67% | Sep 30, 23 |
| 15 | Velan Capital Investment Management LP | 747.41K (3.86%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 16 | Federated Hermes Inc | 712.30K (3.68%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 17 | Sio Capital Management, LLC | 636.30K (3.29%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 18 | Sectoral Asset Management Inc | 525.00K (2.71%) | 346.63K Increased by +66.02% | Sep 30, 23 |
| 19 | Next Century Growth Investors LLC | 473.13K (2.44%) | -301.78K Decreased by -63.78% | Sep 30, 23 |
| 20 | BlackRock Inc | 460.61K (2.38%) | 2.10K Increased by +0.46% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.15M (5.94%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 643.29K (3.32%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | FTGF RY US SmCp Opp A USD Dis(A) | 553.14K (2.86%) | 31.95K Increased by +5.78% | Feb 28, 25 |
| 4 | Royce Small-Cap Opportunity Invmt | 532.97K (2.75%) | 532.97K Increased by +100.00% | Dec 31, 24 |
| 5 | Federated Hermes Kaufmann Growth | 500.00K (2.58%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 6 | Federated Hermes Kaufmann R | 500.00K (2.58%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 7 | Vanguard Institutional Extnd Mkt Idx Tr | 390.95K (2.02%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 8 | iShares Russell 2000 ETF | 359.80K (1.86%) | -2.87K Decreased by -0.80% | Apr 30, 24 |
| 9 | Kennedy Micro Cap | 293.76K (1.52%) | 1.41K Increased by +0.48% | Jun 30, 24 |
| 10 | Federated Hermes Kaufmann Small Cap A | 200.00K (1.03%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 11 | Federated Hermes Kaufmann Small Cap Grow | 200.00K (1.03%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 12 | Paradigm Micro-Cap | 200.00K (1.03%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 13 | Fidelity Extended Market Index | 172.41K (0.89%) | -715.00 Decreased by -0.41% | Jan 31, 26 |
| 14 | Fidelity Small Cap Index | 163.54K (0.85%) | 3.91K Increased by +2.39% | Jun 30, 24 |
| 15 | Fidelity® Small Cap Index | 155.60K (0.80%) | 3.54K Increased by +2.28% | Oct 31, 23 |
| 16 | Jacob Small Cap Growth Investor | 147.00K (0.76%) | 147.00K Increased by +100.00% | Dec 31, 25 |
| 17 | iShares Russell 2000 Growth ETF | 132.15K (0.68%) | -316.00 Decreased by -0.24% | Apr 30, 24 |
| 18 | Next Century Growth Micro Cap Growth | 126.43K (0.65%) | -82.13K Decreased by -64.96% | Sep 30, 23 |
| 19 | Jacob Discovery Fd Instl | 119.78K (0.62%) | 119.78K Increased by +100.00% | Dec 31, 25 |
| 20 | Calamos Timpani Small Cap Growth I | 110.59K (0.57%) | -26.56K Decreased by -24.02% | Mar 31, 24 |