| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Lynx1 Capital Management, LP | 8.02M (16.96%) | 161.80K Increased by +2.02% | Dec 31, 25 |
| 2 | Bvf Inc | 5.23M (11.05%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Adage Capital Partners Gp LLC | 3.50M (7.40%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 4 | Baker Bros Advisors LP | 2.78M (5.89%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 5 | Vanguard Group Inc | 2.48M (5.24%) | 157.82K Increased by +6.37% | Dec 31, 25 |
| 6 | BlackRock Inc | 2.38M (5.04%) | -183.76K Decreased by -7.71% | Sep 30, 25 |
| 7 | Propel Bio Management LLC | 2.09M (4.41%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 8 | Checkpoint Capital LP | 2.02M (4.27%) | 261.66K Increased by +12.97% | Mar 31, 25 |
| 9 | Aberdeen Group PLC | 1.79M (3.78%) | 430.42K Increased by +24.11% | Dec 31, 25 |
| 10 | Deer Management Co. LLC | 1.25M (2.63%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 11 | Renaissance Technologies Corp | 1.14M (2.41%) | 311.15K Increased by +27.27% | Dec 31, 25 |
| 12 | Alphabet Inc | 1.08M (2.28%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 13 | Simplify Asset Management Inc. | 1.05M (2.21%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 14 | Great Point Partners LLC | 940.83K (1.99%) | 940.83K Increased by +100.00% | Jun 30, 24 |
| 15 | StemPoint Capital LP | 860.95K (1.82%) | 15.88K Increased by +1.84% | Sep 30, 24 |
| 16 | Morgan Stanley - Brokerage Accounts | 847.54K (1.79%) | -5.81K Decreased by -0.69% | Sep 30, 25 |
| 17 | State Street Corp | 817.25K (1.73%) | 16.30K Increased by +1.99% | Mar 31, 25 |
| 18 | LMR Partners LLP | 665.53K (1.41%) | 665.53K Increased by +100.00% | Jun 30, 24 |
| 19 | EcoR1 Capital, LLC | 662.83K (1.40%) | -4.34M Decreased by -654.34% | Mar 31, 25 |
| 20 | Two Sigma Investments LLC | 651.18K (1.38%) | 231.78K Increased by +35.59% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.50M (3.17%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Simplify Propel Opportunities ETF | 1.05M (2.21%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 3 | abrdn Life Sciences Investors | 836.78K (1.77%) | -26.48K Decreased by -3.16% | Feb 28, 26 |
| 4 | abrdn Healthcare Investors | 617.29K (1.31%) | -57.11K Decreased by -9.25% | Feb 28, 26 |
| 5 | Vanguard Institutional Extnd Mkt Idx Tr | 577.59K (1.22%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 6 | BlackRock Health Sciences Opps Inv A | 556.65K (1.18%) | -4.17K Decreased by -0.75% | Feb 28, 26 |
| 7 | BlackRock Health Sciences Term Trust | 407.01K (0.86%) | -638.76K Decreased by -156.94% | Dec 31, 25 |
| 8 | Fidelity Small Cap Index | 392.73K (0.83%) | 0.00 Increased by 0.00% | May 31, 25 |
| 9 | Fidelity Extended Market Index | 267.25K (0.57%) | -1.11K Decreased by -0.42% | Jan 31, 26 |
| 10 | iShares Biotechnology ETF | 262.48K (0.56%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 11 | State St Russell Sm/Mid Cp® Indx NL Cl C | 217.61K (0.46%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 12 | State St Russell Sm/Mid Cp® Indx SL Cl I | 217.61K (0.46%) | 0.00 Increased by 0.00% | May 31, 25 |
| 13 | iShares Russell 2000 Growth ETF | 213.91K (0.45%) | 0.00 Increased by 0.00% | May 31, 25 |
| 14 | Fidelity® Extended Market Index | 209.06K (0.44%) | 5.06K Increased by +2.42% | Nov 30, 23 |
| 15 | BIT Biotech Opportunities S | 204.76K (0.43%) | 74.21K Increased by +36.24% | Nov 30, 24 |
| 16 | A4Investments SICAV SIF ACCI IlanaA2EURH | 200.00K (0.42%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 17 | Vanguard Russell 2000 ETF | 191.93K (0.41%) | 1.75K Increased by +0.91% | May 31, 25 |
| 18 | State St Russell Sm Cap® Indx SL Cl I | 164.00K (0.35%) | 0.00 Increased by 0.00% | May 31, 25 |
| 19 | Tocqueville Asset Mgt Multi Cap Equity | 149.70K (0.32%) | 34.00K Increased by +22.71% | Dec 31, 24 |
| 20 | iShares Russell 2000 Value ETF | 120.24K (0.25%) | 0.00 Increased by 0.00% | May 31, 25 |