| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 15.38M (16.09%) | 1.37M Increased by +8.90% | Dec 31, 25 |
| 2 | Artal Group S A | 11.26M (11.78%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 3 | Siren, L.L.C. | 10.83M (11.32%) | 1.58M Increased by +14.55% | Dec 31, 25 |
| 4 | Samsara BioCapital, LLC | 6.90M (7.21%) | 1.28M Increased by +18.63% | Dec 31, 25 |
| 5 | T. Rowe Price Associates, Inc. | 6.88M (7.20%) | -1.88M Decreased by -27.29% | Sep 30, 25 |
| 6 | BlackRock Inc | 6.76M (7.07%) | 64.31K Increased by +0.95% | Sep 30, 25 |
| 7 | Wellington Management Company LLP | 5.76M (6.02%) | 1.21M Increased by +21.07% | Dec 31, 25 |
| 8 | Redmile Group, LLC | 5.22M (5.46%) | 1.32M Increased by +25.21% | Dec 31, 25 |
| 9 | Vanguard Group Inc | 5.20M (5.43%) | 280.54K Increased by +5.40% | Dec 31, 25 |
| 10 | State Street Corporation | 4.17M (4.36%) | 2.01M Increased by +48.21% | Mar 31, 24 |
| 11 | Bellevue Group AG | 4.06M (4.24%) | 812.05K Increased by +20.02% | Dec 31, 25 |
| 12 | State Street Corp | 3.76M (3.94%) | 688.81K Increased by +18.30% | Sep 30, 25 |
| 13 | Orbis Allan Gray Ltd | 3.43M (3.59%) | 3.13M Increased by +91.19% | Dec 31, 25 |
| 14 | Paradigm Biocapital Advisors LP | 3.06M (3.20%) | 1.05M Increased by +34.37% | Dec 31, 25 |
| 15 | HHG PLC | 3.01M (3.15%) | 563.16K Increased by +18.69% | Sep 30, 25 |
| 16 | Jennison Associates LLC | 2.80M (2.92%) | 1.19M Increased by +42.53% | Dec 31, 25 |
| 17 | Eventide Asset Management, LLC | 2.43M (2.54%) | -368.12K Decreased by -15.14% | Dec 31, 25 |
| 18 | NORGES BANK | 2.08M (2.17%) | 904.24K Increased by +43.48% | Dec 31, 25 |
| 19 | Geode Capital Management, LLC | 2.03M (2.13%) | 79.21K Increased by +3.89% | Dec 31, 25 |
| 20 | Hood River Capital Management LLC | 2.03M (2.12%) | 12.37K Increased by +0.61% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 5.46M (5.71%) | 14.64K Increased by +0.27% | Jan 31, 26 |
| 2 | Fidelity Growth Company Fund | 3.87M (4.05%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 3 | Fidelity Growth Compy Commingled Pl O | 3.59M (3.76%) | 36.80K Increased by +1.02% | Aug 31, 24 |
| 4 | BB Biotech AG Ord | 3.24M (3.39%) | 305.67K Increased by +9.44% | Sep 30, 25 |
| 5 | Vanguard Total Stock Mkt Idx Inv | 2.77M (2.90%) | 5.72K Increased by +0.21% | Feb 28, 26 |
| 6 | Vanguard Health Care Inv | 2.75M (2.88%) | 1.10M Increased by +39.90% | Dec 31, 25 |
| 7 | Fidelity® Select Biotechnology | 2.49M (2.60%) | 428.93K Increased by +17.25% | Nov 30, 23 |
| 8 | Vanguard US Total Market Shares ETF | 2.29M (2.40%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 9 | Fidelity® Growth Company | 2.19M (2.29%) | 66.00K Increased by +3.02% | Nov 30, 23 |
| 10 | State Street® SPDR® S&P® Biotech ETF | 2.16M (2.26%) | 11.91K Increased by +0.55% | Feb 28, 26 |
| 11 | iShares Russell 2000 ETF | 2.00M (2.09%) | 2.00M Increased by +100.00% | Feb 28, 26 |
| 12 | US Small-Cap Growth II Equity Comp | 1.85M (1.94%) | -478.26K Decreased by -25.81% | Dec 31, 25 |
| 13 | T. Rowe Price New Horizons | 1.85M (1.94%) | -1.89K Decreased by -0.10% | Jan 31, 26 |
| 14 | Polar Capital Biotech S Inc | 1.75M (1.83%) | 1.68M Increased by +95.95% | Jan 31, 26 |
| 15 | Fidelity Advisor® Biotechnology I | 1.67M (1.74%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 16 | T. Rowe Price Health Sciences | 1.65M (1.73%) | -18.11K Decreased by -1.09% | Jan 31, 26 |
| 17 | Fidelity Select Biotechnology | 1.65M (1.73%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 18 | Eventide Gilead N | 1.46M (1.53%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 19 | T. Rowe Price Integrated US SmCapGrEq | 1.25M (1.31%) | 624.53K Increased by +50.00% | Dec 31, 24 |
| 20 | SPDR® S&P Biotech ETF | 1.22M (1.27%) | 2.71K Increased by +0.22% | Aug 31, 25 |