| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | HHG PLC | 5.31M (10.04%) | 167.11K Increased by +3.15% | Jun 30, 25 |
| 2 | Vivo Capital, LLC | 3.96M (7.49%) | -500.00K Decreased by -12.63% | Jun 30, 25 |
| 3 | Adage Capital Partners Gp LLC | 3.58M (6.76%) | -816.73K Decreased by -22.84% | Jun 30, 25 |
| 4 | T. Rowe Price Associates, Inc. | 3.46M (6.55%) | 1.06M Increased by +30.65% | Jun 30, 25 |
| 5 | FMR Inc | 3.34M (6.31%) | 1.10M Increased by +33.09% | Jun 30, 25 |
| 6 | BlackRock Inc | 2.84M (5.38%) | 931.42K Increased by +32.74% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 2.49M (4.71%) | 621.51K Increased by +24.98% | Jun 30, 25 |
| 8 | venBio Select Advisor LLC | 2.05M (3.88%) | -475.00K Decreased by -23.17% | Jun 30, 25 |
| 9 | Perceptive Advisors LLC | 1.51M (2.85%) | 5.56K Increased by +0.37% | Mar 31, 25 |
| 10 | Citadel Advisors Llc | 1.51M (2.85%) | -70.88K Decreased by -4.71% | Jun 30, 25 |
| 11 | Westfield Capital Management Company, L.P. | 1.43M (2.70%) | 218.51K Increased by +15.28% | Jun 30, 25 |
| 12 | State Street Corp | 1.40M (2.66%) | 235.78K Increased by +16.78% | Jun 30, 25 |
| 13 | RA Capital Management, LLC | 1.24M (2.34%) | 1.24M Increased by +100.00% | Sep 30, 23 |
| 14 | Holocene Advisors, LP | 1.15M (2.18%) | -43.94K Decreased by -3.81% | Jun 30, 25 |
| 15 | COMMODORE CAPITAL LP | 1.15M (2.18%) | -375.00K Decreased by -32.61% | Mar 31, 25 |
| 16 | Fairmount Funds Management LLC | 1.14M (2.16%) | 1.14M Increased by +100.00% | Sep 30, 23 |
| 17 | Vestal Point Capital LP | 1.06M (2.01%) | 340.00K Increased by +32.08% | Dec 31, 24 |
| 18 | Nantahala Capital Management, LLC | 1.00M (1.89%) | -755.67K Decreased by -75.47% | Jun 30, 25 |
| 19 | Alyeska Investment Group, L.P. | 976.11K (1.85%) | 976.11K Increased by +100.00% | Sep 30, 24 |
| 20 | State Street Corporation | 970.57K (1.84%) | 469.17K Increased by +48.34% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.49M (2.83%) | 18.04K Increased by +1.21% | Jul 31, 25 |
| 2 | T. Rowe Price All-Cap Opportunities Fund | 1.27M (2.39%) | 142.86K Increased by +11.28% | Jul 31, 25 |
| 3 | T. Rowe Price US All-Cap Opp Eq Comp | 1.12M (2.12%) | 390.37K Increased by +34.76% | Jun 30, 25 |
| 4 | iShares Russell 2000 ETF | 967.86K (1.83%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 5 | Polar Capital Biotech S Inc | 925.00K (1.75%) | 107.50K Increased by +11.62% | Jul 31, 25 |
| 6 | T. Rowe Price Health Sciences | 924.65K (1.75%) | 338.20K Increased by +36.58% | Jul 31, 25 |
| 7 | Vanguard US Total Market Shares ETF | 913.59K (1.73%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 8 | Janus Henderson Global Life Sciences | 905.88K (1.71%) | -17.78K Decreased by -1.96% | Jun 30, 25 |
| 9 | Janus Henderson Global Life Sciences D | 905.88K (1.71%) | -13.95K Decreased by -1.54% | Jun 30, 25 |
| 10 | Strategic Advisers Fidelity US TtlStk | 849.94K (1.61%) | 808.44K Increased by +95.12% | Jul 31, 25 |
| 11 | Fidelity Select Health Care | 780.00K (1.48%) | 260.00K Increased by +33.33% | Jul 31, 25 |
| 12 | Janus Henderson Glb Life Scn I2 USD | 749.15K (1.42%) | 1.99K Increased by +0.27% | Jul 31, 25 |
| 13 | Janus Global Life Science AUSD | 749.12K (1.42%) | 110.00 Increased by +0.01% | Jun 30, 25 |
| 14 | American Funds SMALLCAP World A | 614.83K (1.16%) | 150.00K Increased by +24.40% | Jun 30, 25 |
| 15 | SPDR® S&P Biotech ETF | 578.58K (1.09%) | 1.29K Increased by +0.22% | Aug 31, 25 |
| 16 | US Small-Cap Growth II Equity Comp | 539.98K (1.02%) | 132.83K Increased by +24.60% | Jun 30, 25 |
| 17 | T. Rowe Price New Horizons | 523.57K (0.99%) | -16.41K Decreased by -3.13% | Jul 31, 25 |
| 18 | Vanguard Institutional Extnd Mkt Idx Tr | 522.36K (0.99%) | 113.28K Increased by +21.69% | Jun 30, 25 |
| 19 | Janus Henderson Triton D | 445.13K (0.84%) | -5.25K Decreased by -1.18% | Jun 30, 25 |
| 20 | Janus Henderson US SMID Cap Growth | 445.13K (0.84%) | -5.25K Decreased by -1.18% | Jun 30, 25 |