| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Federated Hermes Inc | 14.03M (21.44%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 2 | RA Capital Management, LLC | 9.18M (14.02%) | 9.18M Increased by +100.00% | Dec 31, 25 |
| 3 | Opaleye Management Inc | 6.29M (9.60%) | 5.38M Increased by +85.63% | Dec 31, 25 |
| 4 | BlackRock Inc | 5.00M (7.64%) | 922.91K Increased by +18.44% | Sep 30, 25 |
| 5 | Vanguard Group Inc | 4.79M (7.31%) | 378.43K Increased by +7.90% | Dec 31, 25 |
| 6 | Balyasny Asset Management LLC | 4.51M (6.88%) | 2.68M Increased by +59.56% | Dec 31, 25 |
| 7 | Blackstone Inc | 3.02M (4.62%) | -536.39K Decreased by -17.74% | Sep 30, 25 |
| 8 | Mangrove Partners | 2.88M (4.40%) | 584.66K Increased by +20.29% | Sep 30, 25 |
| 9 | Stonepine Capital Management Llc | 2.77M (4.23%) | -303.82K Decreased by -10.97% | Dec 31, 23 |
| 10 | Marshall Wace Asset Management Ltd | 2.73M (4.17%) | -158.17K Decreased by -5.80% | Sep 30, 25 |
| 11 | UBS Group AG | 2.70M (4.12%) | -341.19K Decreased by -12.66% | Sep 30, 25 |
| 12 | First Manhattan Co. LLC | 2.68M (4.09%) | -942.10K Decreased by -35.14% | Dec 31, 23 |
| 13 | Adage Capital Partners Gp LLC | 2.53M (3.86%) | 2.21M Increased by +87.50% | Dec 31, 24 |
| 14 | Affinity Asset Advisors, LLC | 2.35M (3.59%) | 251.14K Increased by +10.68% | Dec 31, 25 |
| 15 | FMR Inc | 2.31M (3.52%) | -10.46M Decreased by -453.63% | Dec 31, 25 |
| 16 | Nantahala Capital Management, LLC | 2.29M (3.50%) | 1.00M Increased by +43.64% | Jun 30, 25 |
| 17 | Vivo Capital, LLC | 2.11M (3.23%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 18 | State Street Corp | 2.09M (3.19%) | 1.26M Increased by +60.31% | Sep 30, 25 |
| 19 | Integral Health Asset Management, LLC | 2.00M (3.05%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | Caxton Corp | 1.99M (3.03%) | 382.83K Increased by +19.27% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Federated Hermes Kaufmann R | 8.49M (12.97%) | 1.50M Increased by +17.72% | Dec 31, 25 |
| 2 | Federated Hermes Kaufmann Growth | 7.48M (11.43%) | 2.11M Increased by +28.25% | Dec 31, 25 |
| 3 | Federated Hermes Kaufmann Small Cap A | 6.18M (9.44%) | 995.00K Increased by +16.10% | Dec 31, 25 |
| 4 | Federated Hermes Kaufmann Small Cap Grow | 4.75M (7.26%) | 995.00K Increased by +20.93% | Dec 31, 25 |
| 5 | Fidelity Select Health Care | 2.80M (4.28%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 2.48M (3.78%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 7 | State Street® SPDR® S&P® Biotech ETF | 2.32M (3.54%) | 12.87K Increased by +0.55% | Feb 28, 26 |
| 8 | Fidelity Advisor Biotechnology I | 1.99M (3.03%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 9 | iShares Russell 2000 ETF | 1.92M (2.93%) | 1.92M Increased by +100.00% | Feb 28, 26 |
| 10 | Fidelity Stock Selector Small Cap | 1.91M (2.92%) | 0.00 Increased by 0.00% | Nov 30, 25 |
| 11 | Fidelity Series Small Cap Opps | 1.65M (2.52%) | 0.00 Increased by 0.00% | Nov 30, 25 |
| 12 | Fidelity Advisor Health Care I | 1.60M (2.44%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 13 | Fidelity Small Cap Growth | 1.34M (2.05%) | 0.00 Increased by 0.00% | Nov 30, 25 |
| 14 | Vanguard US Total Market Shares ETF | 1.08M (1.65%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 15 | Vanguard Institutional Extnd Mkt Idx Tr | 888.66K (1.36%) | 4.64K Increased by +0.52% | Feb 28, 26 |
| 16 | Fidelity Small Cap Index | 781.11K (1.19%) | 915.00 Increased by +0.12% | Dec 31, 25 |
| 17 | Fidelity Small Cap Growth K6 | 676.67K (1.03%) | 0.00 Increased by 0.00% | Nov 30, 25 |
| 18 | Fidelity Select Biotechnology | 631.08K (0.96%) | -9.70K Decreased by -1.54% | Jul 31, 25 |
| 19 | MEDICAL BioHealth EUR Acc | 611.07K (0.93%) | 199.07K Increased by +32.58% | Jun 30, 25 |
| 20 | State St Russell Sm/Mid Cp® Indx SL Cl I | 591.58K (0.90%) | 0.00 Increased by 0.00% | Feb 28, 26 |