| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Perceptive Advisors LLC | 419.10M (755.66%) | 416.69M Increased by +99.42% | Sep 30, 25 |
| 2 | RA Capital Management, LLC | 6.67M (12.02%) | 985.48K Increased by +14.78% | Dec 31, 25 |
| 3 | BlackRock Inc | 6.30M (11.36%) | 34.68K Increased by +0.55% | Sep 30, 25 |
| 4 | Vanguard Group Inc | 6.21M (11.20%) | 1.21M Increased by +19.55% | Dec 31, 25 |
| 5 | Baker Bros Advisors LP | 5.60M (10.11%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 6 | PRIMECAP Management Company | 3.48M (6.27%) | -784.19K Decreased by -22.54% | Dec 31, 25 |
| 7 | State Street Corporation | 3.01M (5.43%) | 807.82K Increased by +26.80% | Mar 31, 24 |
| 8 | NEA Management Company, LLC | 2.91M (5.25%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | JPMorgan Chase & Co | 2.38M (4.28%) | 1.59M Increased by +67.02% | Sep 30, 25 |
| 10 | State Street Corp | 2.03M (3.66%) | 121.05K Increased by +5.97% | Sep 30, 25 |
| 11 | The Goldman Sachs Group Inc | 1.89M (3.41%) | 159.94K Increased by +8.45% | Sep 30, 25 |
| 12 | Goldman Sachs Group Inc | 1.73M (3.13%) | 95.81K Increased by +5.53% | Jun 30, 25 |
| 13 | Federated Hermes Inc | 1.73M (3.12%) | 41.39K Increased by +2.40% | Sep 30, 25 |
| 14 | FMR Inc | 1.71M (3.08%) | -438.87K Decreased by -25.72% | Dec 31, 25 |
| 15 | T. Rowe Price Associates, Inc. | 1.40M (2.52%) | 58.51K Increased by +4.18% | Sep 30, 25 |
| 16 | Geode Capital Management, LLC | 1.38M (2.48%) | 12.90K Increased by +0.94% | Dec 31, 25 |
| 17 | Driehaus Capital Management LLC | 1.29M (2.32%) | -98.55K Decreased by -7.67% | Dec 31, 25 |
| 18 | Westfield Capital Management Company, L.P. | 1.27M (2.28%) | 198.15K Increased by +15.64% | Dec 31, 25 |
| 19 | Polar Capital Holdings PLC | 1.19M (2.14%) | -59.54K Decreased by -5.02% | Dec 31, 25 |
| 20 | HHG PLC | 1.16M (2.09%) | -251.01K Decreased by -21.62% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | PRIMECAP Odyssey Aggressive Growth | 2.16M (3.89%) | -522.28K Decreased by -24.22% | Dec 31, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.11M (3.81%) | 4.17K Increased by +0.20% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 1.92M (3.46%) | 2.33K Increased by +0.12% | Sep 30, 24 |
| 4 | Vanguard Small Cap Index | 1.52M (2.73%) | 4.07K Increased by +0.27% | Feb 28, 26 |
| 5 | iShares Russell 2000 ETF | 1.29M (2.32%) | 1.29M Increased by +100.00% | Feb 28, 26 |
| 6 | PRIMECAP Odyssey Growth | 1.13M (2.05%) | -206.60K Decreased by -18.21% | Dec 31, 25 |
| 7 | Polar Capital Biotech S Inc | 1.00M (1.80%) | 1.00M Increased by +100.00% | Jan 31, 26 |
| 8 | American Funds SMALLCAP World A | 987.85K (1.78%) | 457.45K Increased by +46.31% | Dec 31, 25 |
| 9 | State Street® SPDR® S&P® Biotech ETF | 929.87K (1.68%) | 5.12K Increased by +0.55% | Feb 28, 26 |
| 10 | Vanguard Small Cap Growth Index Inv | 841.70K (1.52%) | 1.37K Increased by +0.16% | Feb 28, 26 |
| 11 | Fidelity® Select Biotechnology | 786.90K (1.42%) | -75.80K Decreased by -9.63% | Nov 30, 23 |
| 12 | Federated Hermes Kaufmann Growth | 707.50K (1.28%) | -48.80K Decreased by -6.90% | Dec 31, 25 |
| 13 | Federated Hermes Kaufmann R | 707.50K (1.28%) | -48.80K Decreased by -6.90% | Dec 31, 25 |
| 14 | BGF World Healthscience A2 USD | 679.21K (1.22%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 15 | Federated Hermes Kaufmann Small Cap A | 673.00K (1.21%) | -85.00K Decreased by -12.63% | Dec 31, 25 |
| 16 | Federated Hermes Kaufmann Small Cap Grow | 673.00K (1.21%) | -85.00K Decreased by -12.63% | Dec 31, 25 |
| 17 | Vanguard Institutional Extnd Mkt Idx Tr | 662.11K (1.19%) | 6.09K Increased by +0.92% | Feb 28, 26 |
| 18 | Pictet Biotech | 659.88K (1.19%) | 659.88K Increased by +100.00% | Mar 31, 24 |
| 19 | BlackRock Health Sciences Term Trust | 630.46K (1.14%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 20 | SPDR® S&P Biotech ETF | 630.00K (1.14%) | 1.41K Increased by +0.22% | Aug 31, 25 |