| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 18.70M (98.89%) | 18.70M Increased by +100.00% | Sep 30, 23 |
| 2 | Samlyn Capital, LLC | 9.67M (51.12%) | 467.10K Increased by +4.83% | Dec 31, 24 |
| 3 | Acadian Asset Management LLC | 7.30M (38.61%) | 7.23M Increased by +99.07% | Mar 31, 25 |
| 4 | Citadel Advisors Llc | 6.95M (36.78%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 5 | Eventide Asset Management, LLC | 6.65M (35.17%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 6 | Almitas Capital LLC | 4.61M (24.38%) | 3.69M Increased by +80.04% | Mar 31, 25 |
| 7 | TANG CAPITAL MANAGEMENT LLC | 3.94M (20.83%) | 3.80M Increased by +96.46% | Sep 30, 23 |
| 8 | Stonepine Capital Management Llc | 3.48M (18.41%) | 3.48M Increased by +100.00% | Mar 31, 24 |
| 9 | State Street Corp | 3.26M (17.23%) | -13.81K Decreased by -0.42% | Mar 31, 25 |
| 10 | D. E. Shaw & Co LP | 2.55M (13.48%) | -3.57M Decreased by -140.21% | Mar 31, 24 |
| 11 | Exome Asset Management LLC | 2.23M (11.81%) | 1.61M Increased by +72.31% | Mar 31, 25 |
| 12 | Monaco Asset Management | 2.03M (10.75%) | 35.65K Increased by +1.75% | Dec 31, 24 |
| 13 | GSA Capital Partners LLP | 1.99M (10.52%) | -3.27M Decreased by -164.12% | Mar 31, 24 |
| 14 | Deep Track Capital, LP | 1.98M (10.45%) | -13.95M Decreased by -705.80% | Dec 31, 24 |
| 15 | Goldman Sachs Group Inc | 1.78M (9.43%) | 15.95K Increased by +0.89% | Sep 30, 24 |
| 16 | Verition Fund Managegment, LLC | 1.74M (9.22%) | 1.65M Increased by +94.84% | Sep 30, 23 |
| 17 | Assenagon Asset Management SA | 1.69M (8.92%) | -778.97K Decreased by -46.17% | Mar 31, 24 |
| 18 | Mackenzie Investments | 1.66M (8.77%) | 719.21K Increased by +43.36% | Mar 31, 25 |
| 19 | Shay Capital LLC | 1.60M (8.44%) | -245.10K Decreased by -15.36% | Sep 30, 24 |
| 20 | UBS O'Connor LLC | 1.58M (8.36%) | 430.09K Increased by +27.20% | Dec 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences I | 6.65M (35.17%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 2 | Vanguard US Total Market Shares ETF | 5.72M (30.27%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | iShares Russell 2000 ETF | 4.62M (24.43%) | 0.00 Increased by 0.00% | May 31, 25 |
| 4 | Pictet Biopharmaceutical Mother | 1.85M (9.76%) | 999.77K Increased by +54.15% | Apr 13, 23 |
| 5 | Fidelity Small Cap Index | 1.83M (9.66%) | 0.00 Increased by 0.00% | May 31, 25 |
| 6 | iShares Russell 2000 Value ETF | 1.66M (8.80%) | 0.00 Increased by 0.00% | May 31, 25 |
| 7 | Fidelity® Extended Market Index | 921.63K (4.87%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 8 | State St Russell Sm/Mid Cp® Indx NL Cl C | 913.93K (4.83%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 9 | State St Russell Sm/Mid Cp® Indx SL Cl I | 913.93K (4.83%) | 0.00 Increased by 0.00% | May 31, 25 |
| 10 | Vanguard Russell 2000 ETF | 892.48K (4.72%) | 8.00K Increased by +0.90% | May 31, 25 |
| 11 | Mackenzie US Small Cap F8 | 706.38K (3.74%) | 47.20K Increased by +6.68% | Apr 30, 25 |
| 12 | Mackenzie US Small Cap A | 659.17K (3.49%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 13 | State St Russell Sm Cap® Indx SL Cl I | 614.40K (3.25%) | 0.00 Increased by 0.00% | May 31, 25 |
| 14 | Vanguard Health Care ETF | 565.83K (2.99%) | -1.44K Decreased by -0.25% | Oct 31, 24 |
| 15 | A4Investments SICAV SIF ACCI IlanaA2EURH | 550.00K (2.91%) | 0.00 Increased by 0.00% | Jan 31, 24 |
| 16 | BlackRock Extended Mkt Composite | 538.85K (2.85%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 17 | Invesco FTSE RAFI US 1500 Small-Mid ETF | 531.74K (2.81%) | 0.00 Increased by 0.00% | Feb 27, 25 |
| 18 | Vanguard Total Stock Mkt Idx Inv | 524.03K (2.77%) | 142.38K Increased by +27.17% | Jul 31, 25 |
| 19 | BlackRock Extended Equity Market K | 469.82K (2.48%) | -453.00 Decreased by -0.10% | Jun 30, 24 |
| 20 | Schwab Small Cap Index | 449.76K (2.38%) | 0.00 Increased by 0.00% | May 31, 25 |