| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Nextech Invest AG | 12.07M (342.86%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | Nextech Invest, Ltd. | 12.07M (342.86%) | 12.07M Increased by +100.00% | Mar 31, 25 |
| 3 | EcoR1 Capital, LLC | 11.33M (321.85%) | -8.04M Decreased by -70.95% | Dec 31, 24 |
| 4 | Bain Capital Life Sciences Investors, LLC | 8.66M (246.15%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | Vanguard Group Inc | 8.38M (238.03%) | 1.32M Increased by +15.76% | Mar 31, 25 |
| 6 | BlackRock Inc | 8.33M (236.56%) | -879.00K Decreased by -10.56% | Mar 31, 25 |
| 7 | Schonfeld Strategic Advisors LLC | 7.61M (216.33%) | 5.49M Increased by +72.16% | Mar 31, 25 |
| 8 | State Street Corporation | 5.50M (156.19%) | 3.17M Increased by +57.63% | Mar 31, 24 |
| 9 | Bellevue Group AG | 5.22M (148.27%) | -800.00 Decreased by -0.02% | Sep 30, 23 |
| 10 | AQR Capital Management LLC | 5.14M (146.15%) | 5.14M Increased by +100.00% | Mar 31, 25 |
| 11 | Citadel Advisors Llc | 4.41M (125.34%) | 1.67M Increased by +37.81% | Sep 30, 24 |
| 12 | Novo A/S | 4.25M (120.75%) | 4.25M Increased by +100.00% | Dec 31, 24 |
| 13 | Rock Springs Capital Management LP | 3.81M (108.38%) | 383.00K Increased by +10.04% | Mar 31, 25 |
| 14 | Balyasny Asset Management LLC | 3.66M (103.87%) | -6.04M Decreased by -165.27% | Mar 31, 24 |
| 15 | VR Adviser, LLC | 3.57M (101.55%) | -6.68M Decreased by -186.99% | Mar 31, 25 |
| 16 | SILVERARC CAPITAL MANAGEMENT, LLC | 3.09M (87.75%) | 3.09M Increased by +100.00% | Mar 31, 25 |
| 17 | Acadian Asset Management LLC | 2.99M (84.94%) | 2.98M Increased by +99.60% | Mar 31, 25 |
| 18 | Boxer Capital Management, LLC | 2.63M (74.87%) | 2.63M Increased by +100.00% | Dec 31, 24 |
| 19 | State Street Corp | 2.60M (73.98%) | -161.03K Decreased by -6.18% | Mar 31, 25 |
| 20 | Cormorant Asset Management, LLC | 2.60M (73.87%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BB Biotech AG Ord | 5.21M (147.91%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 2 | Vanguard US Total Market Shares ETF | 3.47M (98.62%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | SPDR® S&P Biotech ETF | 3.01M (85.48%) | 5.82K Increased by +0.19% | May 31, 24 |
| 4 | Vanguard Explorer Inv | 2.01M (57.02%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 5 | Fidelity Small Cap Index | 1.11M (31.57%) | 0.00 Increased by 0.00% | May 31, 25 |
| 6 | Fidelity® Small Cap Index | 1.02M (28.88%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 7 | State St Russell Sm/Mid Cp® Indx NL Cl C | 839.38K (23.85%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 8 | State St Russell Sm/Mid Cp® Indx SL Cl I | 839.38K (23.85%) | 0.00 Increased by 0.00% | May 31, 25 |
| 9 | iShares Russell 2000 ETF | 569.31K (16.18%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 10 | Vanguard Russell 2000 ETF | 564.71K (16.04%) | 4.82K Increased by +0.85% | May 31, 25 |
| 11 | HealthInvest Sustainable Healthcare E | 538.62K (15.30%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 12 | Fidelity Extended Market Index | 522.39K (14.84%) | -1.36K Decreased by -0.26% | Jun 30, 25 |
| 13 | Fidelity® Extended Market Index | 508.16K (14.44%) | 83.33K Increased by +16.40% | Nov 30, 23 |
| 14 | Bridgeway Ultra-Small Company | 475.50K (13.51%) | 243.20K Increased by +51.15% | Jun 30, 24 |
| 15 | Xtrackers MSCI World Swap ETF 1C | 449.40K (12.77%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | State St Russell Sm Cap® Indx SL Cl I | 414.47K (11.78%) | 0.00 Increased by 0.00% | May 31, 25 |
| 17 | Vanguard VIF Small Co Gr | 408.39K (11.60%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 18 | JPMorgan US Small Company L | 403.74K (11.47%) | -11.73K Decreased by -2.91% | Dec 31, 24 |
| 19 | Rhenman Healthcare Equity L/S RC2 SEK | 400.00K (11.36%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 20 | Direxion Daily S&P Biotech Bull 3X ETF | 299.51K (8.51%) | 0.00 Increased by 0.00% | May 30, 24 |