| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bvf Inc | 19.75M (55.67%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | FMR Inc | 5.73M (16.15%) | -596.47K Decreased by -10.41% | Jun 30, 25 |
| 3 | Deep Track Capital, LP | 4.61M (12.99%) | 4.61M Increased by +100.00% | Dec 31, 25 |
| 4 | Cormorant Asset Management, LLC | 4.36M (12.28%) | 2.36M Increased by +54.21% | Dec 31, 25 |
| 5 | D. E. Shaw & Co LP | 2.48M (6.99%) | 2.48M Increased by +100.00% | Dec 31, 25 |
| 6 | venBio Select Advisor LLC | 2.00M (5.64%) | -2.15M Decreased by -107.50% | Sep 30, 25 |
| 7 | Logos Global Management LP | 1.75M (4.93%) | 1.75M Increased by +100.00% | Dec 31, 25 |
| 8 | Jane Street Group LLC | 1.68M (4.74%) | 1.66M Increased by +98.69% | Dec 31, 25 |
| 9 | Holocene Advisors, LP | 1.59M (4.47%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | Balyasny Asset Management LLC | 1.57M (4.43%) | -128.16K Decreased by -8.16% | Dec 31, 25 |
| 11 | Goldman Sachs Group Inc | 1.28M (3.60%) | -17.04K Decreased by -1.34% | Jun 30, 25 |
| 12 | Westfield Capital Management Company, L.P. | 1.26M (3.55%) | -175.39K Decreased by -13.93% | Jun 30, 25 |
| 13 | Federated Hermes Inc | 1.25M (3.52%) | -20.78K Decreased by -1.66% | Jun 30, 25 |
| 14 | Westfield Capital Management Company, LP | 1.17M (3.29%) | 49.73K Increased by +4.26% | Sep 30, 24 |
| 15 | AllianceBernstein L.P. | 1.14M (3.21%) | 171.93K Increased by +15.11% | Jun 30, 25 |
| 16 | Polar Capital Holdings PLC | 1.10M (3.10%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 17 | T. Rowe Price Investment Management,Inc. | 1.10M (3.09%) | -125.50K Decreased by -11.46% | Mar 31, 24 |
| 18 | Darwin Global Management, Ltd. | 1.04M (2.93%) | 1.04M Increased by +100.00% | Dec 31, 23 |
| 19 | Vivo Capital, LLC | 1.00M (2.82%) | 1.00M Increased by +100.00% | Dec 31, 25 |
| 20 | Paradigm Biocapital Advisors LP | 878.32K (2.48%) | 250.90K Increased by +28.57% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Jupiter Merian Glb Eq AbsRet I USD Acc | 1.18M (3.33%) | 1.18M Increased by +100.00% | Dec 31, 25 |
| 2 | Polar Capital Biotech S Inc | 1.00M (2.82%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 3 | Fidelity Growth Compy Commingled Pl S | 981.02K (2.77%) | 273.63K Increased by +27.89% | Jul 31, 25 |
| 4 | T. Rowe Price Health Sciences | 747.36K (2.11%) | 5.33K Increased by +0.71% | Jan 31, 26 |
| 5 | Fidelity Growth Company Fund | 740.92K (2.09%) | 248.13K Increased by +33.49% | Jul 31, 25 |
| 6 | Federated Hermes Kaufmann Growth | 665.00K (1.87%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 7 | Federated Hermes Kaufmann R | 665.00K (1.87%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 8 | US Small-Cap Growth II Equity Comp | 523.89K (1.48%) | -134.19K Decreased by -25.62% | Jun 30, 25 |
| 9 | Fidelity Select Health Care | 520.00K (1.47%) | -150.00K Decreased by -28.85% | Jul 31, 25 |
| 10 | Federated Hermes Kaufmann Small Cap A | 503.00K (1.42%) | -16.00K Decreased by -3.18% | Jun 30, 25 |
| 11 | Federated Hermes Kaufmann Small Cap Grow | 503.00K (1.42%) | -16.00K Decreased by -3.18% | Jun 30, 25 |
| 12 | Fidelity Contrafund | 494.78K (1.39%) | -454.00 Decreased by -0.09% | Mar 31, 24 |
| 13 | Fidelity® Contrafund® | 493.74K (1.39%) | 80.19K Increased by +16.24% | Oct 31, 23 |
| 14 | Fidelity Growth Compy Commingled Pl O | 442.87K (1.25%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 15 | apo Medical Opportunities R | 428.89K (1.21%) | 95.00K Increased by +22.15% | Dec 31, 25 |
| 16 | T. Rowe Price Small-Cap Stock | 421.42K (1.19%) | 31.52K Increased by +7.48% | Mar 31, 24 |
| 17 | T. Rowe Price US Small-Cap Core Equity | 421.42K (1.19%) | 31.52K Increased by +7.48% | Mar 31, 24 |
| 18 | Pictet-Biotech P USD | 406.15K (1.14%) | -58.93K Decreased by -14.51% | Jul 31, 23 |
| 19 | Fidelity® Blue Chip Growth | 396.52K (1.12%) | -679.00 Decreased by -0.17% | Oct 31, 23 |
| 20 | Strategic Advisers Fidelity US TtlStk | 394.67K (1.11%) | 3.39K Increased by +0.86% | May 31, 25 |