| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Bellevue Group AG | 9.92M (17.84%) | -9.97K Decreased by -0.10% | Jun 30, 25 |
| 2 | Armistice Capital, LLC | 6.32M (11.38%) | 364.00K Increased by +5.76% | Dec 31, 25 |
| 3 | venBio Select Advisor LLC | 6.15M (11.06%) | 6.15M Increased by +100.00% | Mar 31, 24 |
| 4 | State Street Corporation | 4.39M (7.90%) | 2.22M Increased by +50.47% | Mar 31, 24 |
| 5 | Vanguard Group Inc | 4.23M (7.60%) | 2.71K Increased by +0.06% | Dec 31, 25 |
| 6 | Renaissance Technologies Corp | 2.91M (5.23%) | 1.21M Increased by +41.51% | Dec 31, 25 |
| 7 | T. Rowe Price Investment Management,Inc. | 2.77M (4.98%) | -2.87M Decreased by -103.83% | Mar 31, 24 |
| 8 | Acadian Asset Management LLC | 2.52M (4.53%) | 2.47M Increased by +98.03% | Sep 30, 25 |
| 9 | RA Capital Management, LLC | 2.08M (3.75%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 10 | Millennium Management LLC | 1.97M (3.55%) | -142.39K Decreased by -7.21% | Dec 31, 25 |
| 11 | Wasatch Advisors LP | 1.79M (3.21%) | -163.93K Decreased by -9.18% | Dec 31, 25 |
| 12 | EcoR1 Capital, LLC | 1.60M (2.88%) | 1.60M Increased by +100.00% | Jun 30, 25 |
| 13 | BlackRock Inc | 1.54M (2.77%) | -278.83K Decreased by -18.12% | Sep 30, 25 |
| 14 | JPMorgan Chase & Co | 1.51M (2.72%) | 1.05M Increased by +69.54% | Sep 30, 25 |
| 15 | State Street Corp | 1.41M (2.54%) | -53.22K Decreased by -3.78% | Mar 31, 25 |
| 16 | Wasatch Advisors Inc. | 1.30M (2.33%) | -111.96K Decreased by -8.63% | Dec 31, 23 |
| 17 | Marshall Wace Asset Management Ltd | 1.28M (2.31%) | 655.03K Increased by +50.99% | Dec 31, 25 |
| 18 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.26M (2.26%) | -5.52K Decreased by -0.44% | Dec 31, 23 |
| 19 | Jane Street Group LLC | 1.25M (2.26%) | 408.23K Increased by +32.53% | Dec 31, 25 |
| 20 | T. Rowe Price Associates, Inc. | 1.25M (2.26%) | -82.78K Decreased by -6.60% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BB Biotech AG Ord | 9.92M (17.84%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 2 | SPDR® S&P Biotech ETF | 2.78M (5.00%) | -37.04K Decreased by -1.33% | Apr 30, 24 |
| 3 | Vanguard US Total Market Shares ETF | 2.00M (3.60%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 1.93M (3.46%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 5 | Wasatch Ultra Growth | 1.66M (2.99%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 6 | Wasatch Micro Cap | 773.76K (1.39%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 7 | T. Rowe Price New Horizons | 750.71K (1.35%) | 750.71K Increased by +100.00% | Mar 31, 24 |
| 8 | US Small-Cap Growth II Equity Comp | 750.71K (1.35%) | 750.71K Increased by +100.00% | Mar 31, 24 |
| 9 | T. Rowe Price Small-Cap Stock | 707.16K (1.27%) | -665.30K Decreased by -94.08% | Mar 31, 24 |
| 10 | T. Rowe Price US Small-Cap Core Equity | 707.16K (1.27%) | -665.30K Decreased by -94.08% | Mar 31, 24 |
| 11 | T. Rowe Price Small-Cap Value | 679.96K (1.22%) | -966.34K Decreased by -142.12% | Mar 31, 24 |
| 12 | T. Rowe Price U.S. SC Core Eq Tr-Z | 670.71K (1.21%) | 70.60K Increased by +10.53% | Dec 31, 23 |
| 13 | Vanguard Institutional Extnd Mkt Idx Tr | 651.75K (1.17%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 14 | Fidelity Small Cap Index | 633.43K (1.14%) | -6.51K Decreased by -1.03% | May 31, 25 |
| 15 | Fidelity® Small Cap Index | 588.71K (1.06%) | 17.84K Increased by +3.03% | Oct 31, 23 |
| 16 | Federated Hermes MDT SCC Institutional | 550.65K (0.99%) | -86.61K Decreased by -15.73% | Dec 31, 23 |
| 17 | T. Rowe Price Instl Small-Cap Stock | 523.38K (0.94%) | 113.70K Increased by +21.72% | Dec 31, 23 |
| 18 | JPMorgan Small Cap Value I | 510.51K (0.92%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 19 | State St Russell Sm/Mid Cp® Indx NL Cl C | 476.20K (0.86%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 20 | State St Russell Sm/Mid Cp® Indx SL Cl I | 476.20K (0.86%) | 0.00 Increased by 0.00% | May 31, 25 |