| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Baker Bros Advisors LP | 19.92M (59.25%) | 2.61M Increased by +13.10% | Dec 31, 25 |
| 2 | BlackRock Inc | 2.95M (8.78%) | -627.06K Decreased by -21.24% | Sep 30, 25 |
| 3 | Vanguard Group Inc | 2.31M (6.88%) | 363.10K Increased by +15.70% | Dec 31, 25 |
| 4 | Point72 Asset Management, L.P. | 2.17M (6.45%) | -670.19K Decreased by -30.93% | Dec 31, 25 |
| 5 | BRAIDWELL LP | 2.07M (6.17%) | 2.07M Increased by +100.00% | Dec 31, 25 |
| 6 | EcoR1 Capital, LLC | 1.61M (4.80%) | 1.61M Increased by +100.00% | Mar 31, 24 |
| 7 | RTW INVESTMENTS, LLC | 1.49M (4.43%) | 1.49M Increased by +100.00% | Dec 31, 25 |
| 8 | TCG Crossover Management, LLC | 1.45M (4.30%) | 300.00K Increased by +20.75% | Dec 31, 25 |
| 9 | ICONIQ Capital, LLC | 1.27M (3.77%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | Boxer Capital Management, LLC | 1.14M (3.38%) | 386.00K Increased by +33.98% | Dec 31, 25 |
| 11 | SILVERARC CAPITAL MANAGEMENT, LLC | 1.02M (3.04%) | 23.12K Increased by +2.26% | Dec 31, 25 |
| 12 | Acadian Asset Management LLC | 969.91K (2.88%) | 949.38K Increased by +97.88% | Sep 30, 25 |
| 13 | Geode Capital Management, LLC | 897.69K (2.67%) | 96.25K Increased by +10.72% | Dec 31, 25 |
| 14 | Artisan Partners Limited Partnership | 836.51K (2.49%) | 836.51K Increased by +100.00% | Dec 31, 25 |
| 15 | State Street Corp | 832.44K (2.48%) | -4.78K Decreased by -0.57% | Sep 30, 25 |
| 16 | Adage Capital Partners Gp LLC | 785.00K (2.33%) | -550.00K Decreased by -70.06% | Dec 31, 25 |
| 17 | Renaissance Technologies Corp | 764.14K (2.27%) | 61.54K Increased by +8.05% | Jun 30, 25 |
| 18 | State Street Corporation | 747.50K (2.22%) | 27.06K Increased by +3.62% | Mar 31, 24 |
| 19 | Newtyn Management LLC | 740.50K (2.20%) | -189.50K Decreased by -25.59% | Sep 30, 24 |
| 20 | Dimensional Fund Advisors, Inc. | 731.54K (2.18%) | 48.00K Increased by +6.56% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.23M (3.65%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | State Street® SPDR® S&P® Biotech ETF | 990.79K (2.95%) | 5.49K Increased by +0.55% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 982.01K (2.92%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 801.33K (2.38%) | 81.89K Increased by +10.22% | Feb 28, 26 |
| 5 | BlackRock Advantage Small Cap Core Instl | 523.83K (1.56%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 6 | Artisan International Small-Mid Investor | 516.03K (1.53%) | 516.03K Increased by +100.00% | Dec 31, 25 |
| 7 | Artisan Non-U.S. Small-Mid Growth Comp | 516.03K (1.53%) | 516.03K Increased by +100.00% | Dec 31, 25 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 430.73K (1.28%) | 2.12K Increased by +0.49% | Feb 28, 26 |
| 9 | iShares Biotechnology ETF | 422.50K (1.26%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 10 | Fidelity Small Cap Index | 321.04K (0.95%) | -9.34K Decreased by -2.91% | Dec 31, 25 |
| 11 | Fidelity® Small Cap Index | 302.77K (0.90%) | 5.66K Increased by +1.87% | Oct 31, 23 |
| 12 | iShares Russell 2000 Value ETF | 284.28K (0.85%) | -47.91K Decreased by -16.85% | Feb 28, 26 |
| 13 | Federated Hermes MDT SCC Institutional | 244.23K (0.73%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 14 | Federated Hermes MDT Small Cap Core IS | 244.23K (0.73%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | State St Russell Sm/Mid Cp® Indx NL Cl C | 225.22K (0.67%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 16 | State St Russell Sm/Mid Cp® Indx SL Cl I | 225.22K (0.67%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 17 | T. Rowe Price Small-Cap Value | 223.69K (0.67%) | 223.69K Increased by +100.00% | Jan 31, 26 |
| 18 | Fidelity Extended Market Index | 206.25K (0.61%) | -856.00 Decreased by -0.42% | Jan 31, 26 |
| 19 | Invesco Dorsey Wright SmallCap Momt ETF | 197.93K (0.59%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 20 | Fidelity Enhanced Small Cap ETF | 192.62K (0.57%) | 0.00 Increased by 0.00% | Feb 27, 26 |