| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | VR Adviser, LLC | 6.73M (24.70%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Frazier Life Sciences Management, L.P. | 5.04M (18.50%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Suvretta Capital Management, LLC | 4.77M (17.51%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | TANG CAPITAL MANAGEMENT LLC | 4.57M (16.79%) | -468.27K Decreased by -10.24% | Dec 31, 25 |
| 5 | BlackRock Inc | 3.13M (11.48%) | -3.38K Decreased by -0.11% | Sep 30, 25 |
| 6 | Millennium Management LLC | 2.90M (10.63%) | 800.44K Increased by +27.63% | Dec 31, 25 |
| 7 | Capital World Investors | 2.81M (10.31%) | -369.00K Decreased by -13.14% | Dec 31, 25 |
| 8 | Vanguard Group Inc | 2.51M (9.21%) | 7.90K Increased by +0.31% | Dec 31, 25 |
| 9 | SILVERARC CAPITAL MANAGEMENT, LLC | 2.43M (8.91%) | 1.06M Increased by +43.83% | Dec 31, 25 |
| 10 | Point72 Asset Management, L.P. | 2.28M (8.38%) | 2.28M Increased by +100.00% | Dec 31, 25 |
| 11 | Tudor Investment Corp Et AL | 2.00M (7.34%) | 2.00M Increased by +100.00% | Sep 30, 25 |
| 12 | Woodline Partners LP | 1.92M (7.05%) | 428.00 Increased by +0.02% | Dec 31, 25 |
| 13 | Vestal Point Capital LP | 1.89M (6.94%) | 1.14M Increased by +60.32% | Dec 31, 25 |
| 14 | Kynam Capital Management, LP | 1.81M (6.65%) | 1.20M Increased by +66.53% | Dec 31, 25 |
| 15 | The Goldman Sachs Group Inc | 1.80M (6.61%) | 1.67M Increased by +92.53% | Sep 30, 25 |
| 16 | Parkman Healthcare Partners LLC | 1.77M (6.49%) | 33.51K Increased by +1.89% | Dec 31, 25 |
| 17 | Boxer Capital LLC | 1.59M (5.84%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 18 | Boxer Capital Management, LLC | 1.59M (5.84%) | 1.59M Increased by +100.00% | Dec 31, 24 |
| 19 | State Street Corp | 1.58M (5.78%) | 225.96K Increased by +14.34% | Sep 30, 25 |
| 20 | Adage Capital Partners Gp LLC | 1.42M (5.21%) | -630.21K Decreased by -44.39% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | American Funds SMALLCAP World A | 2.81M (10.31%) | -369.00K Decreased by -13.14% | Dec 31, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.35M (4.96%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 1.20M (4.40%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | APO Medical Opportunities R | 1.17M (4.28%) | 866.80K Increased by +74.33% | Jul 31, 25 |
| 5 | International Biotechnology Ord | 1.16M (4.25%) | 506.51K Increased by +43.72% | Sep 30, 25 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 1.09M (4.01%) | 6.05K Increased by +0.55% | Feb 28, 26 |
| 7 | MEDICAL BioHealth EUR Acc | 979.33K (3.60%) | -520.12K Decreased by -53.11% | Jan 31, 26 |
| 8 | iShares Russell 2000 ETF | 928.97K (3.41%) | 446.84K Increased by +48.10% | Feb 28, 26 |
| 9 | apo Medical Opportunities R | 738.91K (2.71%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 10 | SPDR® S&P Biotech ETF | 571.42K (2.10%) | 1.27K Increased by +0.22% | Aug 31, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 436.14K (1.60%) | 5.88K Increased by +1.35% | Feb 28, 26 |
| 12 | Fidelity Small Cap Index | 376.05K (1.38%) | -9.40K Decreased by -2.50% | Dec 31, 25 |
| 13 | SEB Läkemedelsfond | 351.31K (1.29%) | 351.31K Increased by +100.00% | Jan 31, 26 |
| 14 | Candriam Eqs L Biotech C USD Cap | 350.00K (1.28%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 15 | iShares Russell 2000 Growth ETF | 325.69K (1.20%) | 325.69K Increased by +100.00% | Feb 28, 26 |
| 16 | Principal SmallCap Growth I Instl | 322.56K (1.18%) | 322.19K Increased by +99.88% | Jan 31, 26 |
| 17 | Emerald Growth A | 300.12K (1.10%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 18 | iShares Russell 2000 Value ETF | 286.26K (1.05%) | -380.00 Decreased by -0.13% | May 30, 24 |
| 19 | iShares Biotechnology ETF | 283.89K (1.04%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 20 | Fidelity® Small Cap Index | 233.79K (0.86%) | 5.15K Increased by +2.20% | Oct 31, 23 |