| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 16.55M (17.55%) | 3.49M Increased by +21.11% | Dec 31, 25 |
| 2 | T. Rowe Price Investment Management,Inc. | 14.64M (15.52%) | 6.22M Increased by +42.49% | Dec 31, 25 |
| 3 | Point72 Asset Management, L.P. | 7.03M (7.46%) | 2.21M Increased by +31.42% | Dec 31, 25 |
| 4 | Vanguard Group Inc | 6.04M (6.40%) | 1.14M Increased by +18.96% | Dec 31, 25 |
| 5 | BlackRock Inc | 5.82M (6.17%) | 52.04K Increased by +0.89% | Sep 30, 25 |
| 6 | Redmile Group, LLC | 5.72M (6.06%) | 695.00K Increased by +12.15% | Dec 31, 25 |
| 7 | Enavate Sciences GP, LLC | 4.77M (5.06%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | PRIMECAP Management Company | 4.69M (4.97%) | 1.67M Increased by +35.59% | Dec 31, 25 |
| 9 | T. Rowe Price Associates, Inc. | 3.74M (3.97%) | 760.69K Increased by +20.32% | Sep 30, 25 |
| 10 | Driehaus Capital Management LLC | 3.71M (3.93%) | 3.01M Increased by +81.20% | Dec 31, 25 |
| 11 | Opaleye Management Inc | 3.53M (3.74%) | -20.42K Decreased by -0.58% | Jun 30, 25 |
| 12 | EcoR1 Capital, LLC | 2.86M (3.03%) | -1.22M Decreased by -42.86% | Dec 31, 25 |
| 13 | State Street Corp | 2.80M (2.97%) | 283.06K Increased by +10.09% | Sep 30, 25 |
| 14 | Geode Capital Management, LLC | 2.36M (2.50%) | 466.81K Increased by +19.77% | Dec 31, 25 |
| 15 | Jefferies Financial Group Inc | 2.10M (2.23%) | 14.34K Increased by +0.68% | Sep 30, 25 |
| 16 | The Toronto-Dominion Bank | 2.09M (2.21%) | 2.09M Increased by +100.00% | Jun 30, 25 |
| 17 | Readystate Asset Management LP | 1.84M (1.95%) | 524.92K Increased by +28.48% | Dec 31, 25 |
| 18 | Morgan Stanley - Brokerage Accounts | 1.83M (1.94%) | 1.43M Increased by +77.95% | Sep 30, 25 |
| 19 | Citadel Advisors Llc | 1.74M (1.85%) | 899.57K Increased by +51.68% | Dec 31, 25 |
| 20 | Sofinnova Ventures | 1.62M (1.72%) | 1.18M Increased by +73.06% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Fidelity Growth Compy Commingled Pl S | 6.19M (6.56%) | 33.02K Increased by +0.53% | Jan 31, 26 |
| 2 | T. Rowe Price Small-Cap Stock | 5.25M (5.56%) | 119.97K Increased by +2.29% | Jan 31, 26 |
| 3 | T. Rowe Price US Small-Cap Core Equity | 5.13M (5.44%) | 2.01M Increased by +39.29% | Dec 31, 25 |
| 4 | Fidelity Growth Company Fund | 4.51M (4.78%) | 86.70K Increased by +1.92% | Jan 31, 26 |
| 5 | PRIMECAP Odyssey Aggressive Growth | 3.81M (4.04%) | 1.14M Increased by +29.91% | Dec 31, 25 |
| 6 | Vanguard Total Stock Mkt Idx Inv | 3.14M (3.33%) | 7.82K Increased by +0.25% | Feb 28, 26 |
| 7 | T. Rowe Price Instl Small-Cap Stock | 2.84M (3.02%) | 65.14K Increased by +2.29% | Jan 31, 26 |
| 8 | T. Rowe Price U.S. SC Core Eq Tr-D | 2.36M (2.50%) | 914.28K Increased by +38.75% | Dec 31, 25 |
| 9 | iShares Russell 2000 ETF | 2.27M (2.41%) | 2.27M Increased by +100.00% | Feb 28, 26 |
| 10 | Fidelity Select Biotechnology | 2.13M (2.26%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 11 | State Street® SPDR® S&P® Biotech ETF | 1.90M (2.01%) | 10.46K Increased by +0.55% | Feb 28, 26 |
| 12 | Fidelity Growth Compy Commingled Pl O | 1.79M (1.89%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 13 | Vanguard US Total Market Shares ETF | 1.64M (1.74%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 14 | T. Rowe Price Health Sciences | 1.55M (1.64%) | -625.00K Decreased by -40.42% | Jan 31, 26 |
| 15 | T. Rowe Price U.S. SC Core Eq Tr-Z | 1.37M (1.46%) | 449.50K Increased by +32.73% | Mar 31, 25 |
| 16 | Fidelity Growth Company K6 | 1.32M (1.39%) | 8.61K Increased by +0.65% | Jan 31, 26 |
| 17 | Fidelity Series Growth Company | 1.22M (1.30%) | 20.00K Increased by +1.63% | Jan 31, 26 |
| 18 | Vanguard Institutional Extnd Mkt Idx Tr | 1.13M (1.20%) | 8.47K Increased by +0.75% | Feb 28, 26 |
| 19 | JPM Global Healthcare C (acc) USD | 1.05M (1.11%) | -28.21K Decreased by -2.70% | Feb 28, 26 |
| 20 | Polar Capital Biotech S Inc | 1.00M (1.06%) | 0.00 Increased by 0.00% | Jul 31, 25 |