| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 63.77M (12.49%) | 3.39M Increased by +5.32% | Dec 31, 25 |
| 2 | BlackRock Inc | 46.61M (9.13%) | -3.42M Decreased by -7.33% | Sep 30, 25 |
| 3 | RTW INVESTMENTS, LLC | 44.11M (8.64%) | 44.11M Increased by +100.00% | Sep 30, 24 |
| 4 | Vanguard Group Inc | 35.66M (6.98%) | 1.24M Increased by +3.47% | Dec 31, 25 |
| 5 | Deep Track Capital, LP | 32.51M (6.37%) | -8.59M Decreased by -26.41% | Dec 31, 25 |
| 6 | State Street Corporation | 31.60M (6.19%) | 5.98M Increased by +18.92% | Mar 31, 24 |
| 7 | Vivo Capital, LLC | 27.23M (5.33%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | State Street Corp | 26.62M (5.21%) | 2.99M Increased by +11.22% | Sep 30, 25 |
| 9 | Soleus Capital Management, L.P. | 23.29M (4.56%) | 6.00M Increased by +25.76% | Dec 31, 25 |
| 10 | Holocene Advisors, LP | 22.20M (4.35%) | 4.02M Increased by +18.13% | Dec 31, 24 |
| 11 | Adage Capital Partners Gp LLC | 21.80M (4.27%) | -7.08M Decreased by -32.45% | Dec 31, 24 |
| 12 | The Goldman Sachs Group Inc | 21.31M (4.17%) | 11.49M Increased by +53.93% | Sep 30, 25 |
| 13 | HHG PLC | 18.89M (3.70%) | -8.19M Decreased by -43.35% | Mar 31, 25 |
| 14 | Eversept Partners, LP | 17.66M (3.46%) | 5.06M Increased by +28.66% | Dec 31, 25 |
| 15 | TCG Crossover Management, LLC | 17.39M (3.41%) | -5.98M Decreased by -34.41% | Mar 31, 24 |
| 16 | Farallon Capital Management, L.L.C. | 16.84M (3.30%) | 9.34M Increased by +55.48% | Jun 30, 24 |
| 17 | ClearBridge Advisors, LLC | 14.24M (2.79%) | 17.98K Increased by +0.13% | Dec 31, 25 |
| 18 | Wellington Management Company LLP | 13.51M (2.65%) | 847.71K Increased by +6.27% | Dec 31, 24 |
| 19 | Geode Capital Management, LLC | 13.03M (2.55%) | -96.20K Decreased by -0.74% | Dec 31, 25 |
| 20 | NEA Management Company, LLC | 12.78M (2.50%) | -10.00M Decreased by -78.27% | Mar 31, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 20.05M (3.93%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 17.83M (3.49%) | 17.67K Increased by +0.10% | Sep 30, 24 |
| 3 | BioPharma Credit Ord | 14.12M (2.77%) | 14.12M Increased by +100.00% | Dec 31, 24 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 13.68M (2.68%) | 75.84K Increased by +0.55% | Feb 28, 26 |
| 5 | iShares Russell 2000 ETF | 13.13M (2.57%) | 5.72M Increased by +43.57% | Feb 28, 26 |
| 6 | SPDR® S&P Biotech ETF | 10.09M (1.98%) | 22.55K Increased by +0.22% | Aug 31, 25 |
| 7 | Fidelity Select Biotechnology | 9.04M (1.77%) | 1.04M Increased by +11.51% | Jan 31, 26 |
| 8 | Vanguard Explorer Inv | 8.78M (1.72%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 9 | Eventide Healthcare & Life Sciences I | 7.07M (1.38%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 10 | ClearBridge Small Cap Growth A | 6.32M (1.24%) | 1.02M Increased by +16.15% | Feb 28, 26 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 5.88M (1.15%) | 9.87K Increased by +0.17% | Feb 28, 26 |
| 12 | Fidelity Small Cap Index | 5.37M (1.05%) | -214.21K Decreased by -3.99% | Dec 31, 25 |
| 13 | ClearBridge Small Cap Growth | 5.30M (1.04%) | 1.53M Increased by +28.86% | Jan 31, 26 |
| 14 | Fidelity® Small Cap Index | 4.81M (0.94%) | 131.18K Increased by +2.73% | Oct 31, 23 |
| 15 | Xtrackers MSCI World Swap ETF 1C | 4.66M (0.91%) | -29.36K Decreased by -0.63% | Dec 31, 25 |
| 16 | iShares Russell 2000 Growth ETF | 4.54M (0.89%) | 1.33M Increased by +29.34% | Feb 28, 26 |
| 17 | iShares Biotechnology ETF | 4.51M (0.88%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 18 | Fidelity Growth Compy Commingled Pl O | 4.29M (0.84%) | 0.00 Increased by 0.00% | Aug 31, 24 |
| 19 | State St Russell Sm/Mid Cp® Indx NL Cl C | 3.47M (0.68%) | 14.43K Increased by +0.42% | Apr 30, 25 |
| 20 | State St Russell Sm/Mid Cp® Indx SL Cl I | 3.45M (0.68%) | 0.00 Increased by 0.00% | Feb 28, 26 |