| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Suvretta Capital Management, LLC | 6.56M (15.03%) | 1.18M Increased by +17.99% | Dec 31, 25 |
| 2 | RA Capital Management, LLC | 6.05M (13.87%) | -4.18M Decreased by -68.97% | Dec 31, 25 |
| 3 | RTW INVESTMENTS, LLC | 5.85M (13.39%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 4 | TCG Crossover Management, LLC | 5.25M (12.03%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 5 | Nantahala Capital Management, LLC | 4.29M (9.84%) | -377.44K Decreased by -8.79% | Dec 31, 25 |
| 6 | BlackRock Inc | 3.71M (8.49%) | -672.27K Decreased by -18.14% | Sep 30, 25 |
| 7 | Vanguard Group Inc | 3.56M (8.16%) | 560.09K Increased by +15.73% | Dec 31, 25 |
| 8 | BRAIDWELL LP | 3.06M (7.01%) | 2.84M Increased by +92.83% | Dec 31, 25 |
| 9 | COWEN AND COMPANY, LLC | 2.96M (6.79%) | -749.81K Decreased by -25.30% | Jun 30, 24 |
| 10 | Point72 Asset Management, L.P. | 2.40M (5.49%) | 2.40M Increased by +100.00% | Dec 31, 25 |
| 11 | TRV GP IV, LLC | 2.34M (5.37%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 12 | Siren, L.L.C. | 1.95M (4.47%) | 1.95M Increased by +100.00% | Dec 31, 25 |
| 13 | D. E. Shaw & Co LP | 1.91M (4.38%) | 464.33K Increased by +24.26% | Dec 31, 25 |
| 14 | First Turn Management LLC | 1.89M (4.34%) | 1.89M Increased by +100.00% | Dec 31, 25 |
| 15 | FMR Inc | 1.72M (3.95%) | -3.61M Decreased by -209.16% | Sep 30, 24 |
| 16 | Adage Capital Partners Gp LLC | 1.70M (3.89%) | -732.00K Decreased by -43.06% | Dec 31, 25 |
| 17 | Morgan Stanley - Brokerage Accounts | 1.53M (3.51%) | 1.18M Increased by +77.11% | Dec 31, 24 |
| 18 | MPM Oncology Impact Management LP | 1.44M (3.31%) | 307.74K Increased by +21.30% | Jun 30, 24 |
| 19 | Jefferies Financial Group Inc | 1.43M (3.28%) | 281.59K Increased by +19.65% | Jun 30, 24 |
| 20 | Ikarian Capital, LLC | 1.38M (3.15%) | 86.25K Increased by +6.27% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 2.07M (4.75%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 1.85M (4.24%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Fidelity Growth Compy Commingled Pl O | 1.81M (4.15%) | 0.00 Increased by 0.00% | May 31, 24 |
| 4 | Fidelity® Select Biotechnology | 1.56M (3.57%) | -136.10K Decreased by -8.73% | Nov 30, 23 |
| 5 | abrdn Life Sciences Investors | 1.45M (3.31%) | 78.67K Increased by +5.44% | Feb 28, 26 |
| 6 | Fidelity Select Biotechnology | 1.26M (2.88%) | 0.00 Increased by 0.00% | May 31, 24 |
| 7 | iShares Russell 2000 ETF | 1.06M (2.42%) | 311.47K Increased by +29.50% | Feb 28, 26 |
| 8 | Fidelity® Growth Company | 869.67K (1.99%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 9 | Select Pharmaceuticals Port | 762.00K (1.75%) | 0.00 Increased by 0.00% | Nov 30, 23 |
| 10 | Fidelity Select Pharmaceuticals Port | 683.60K (1.57%) | 0.00 Increased by 0.00% | May 31, 24 |
| 11 | abrdn Healthcare Investors | 543.75K (1.25%) | 543.75K Increased by +100.00% | Feb 28, 26 |
| 12 | Vanguard Institutional Extnd Mkt Idx Tr | 528.54K (1.21%) | 6.22K Increased by +1.18% | Feb 28, 26 |
| 13 | Fidelity Growth Compy Commingled Pl S | 494.64K (1.13%) | -295.57K Decreased by -59.75% | Nov 30, 24 |
| 14 | Fidelity® Growth Company K6 | 471.79K (1.08%) | -51.29K Decreased by -10.87% | Nov 30, 23 |
| 15 | Simplify Propel Opportunities ETF | 465.00K (1.07%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 16 | iShares Biotechnology ETF | 438.77K (1.01%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 17 | SPDR® S&P Pharmaceuticals ETF | 436.70K (1.00%) | 0.00 Increased by 0.00% | Nov 30, 24 |
| 18 | Fidelity Small Cap Index | 423.17K (0.97%) | -10.72K Decreased by -2.53% | Dec 31, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx NL Cl C | 368.38K (0.84%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 20 | State St Russell Sm/Mid Cp® Indx SL Cl I | 368.38K (0.84%) | 0.00 Increased by 0.00% | Feb 28, 26 |