| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 29.70M (9.54%) | 168.67K Increased by +0.57% | Dec 31, 25 |
| 2 | Wellington Management Company LLP | 29.12M (9.35%) | -76.66K Decreased by -0.26% | Jun 30, 25 |
| 3 | BlackRock Inc | 25.85M (8.30%) | -1.68M Decreased by -6.51% | Sep 30, 25 |
| 4 | venBio Select Advisor LLC | 15.03M (4.82%) | -2.98M Decreased by -19.80% | Sep 30, 25 |
| 5 | State Street Corporation | 12.44M (4.00%) | -720.58K Decreased by -5.79% | Mar 31, 24 |
| 6 | Millennium Management LLC | 11.81M (3.79%) | 4.39M Increased by +37.16% | Sep 30, 25 |
| 7 | State Street Corp | 11.56M (3.71%) | -5.16K Decreased by -0.04% | Sep 30, 25 |
| 8 | Pentwater Capital Management LP | 11.50M (3.69%) | 11.50M Increased by +100.00% | Dec 31, 25 |
| 9 | Bellevue Group AG | 10.74M (3.45%) | 10.74M Increased by +100.00% | Dec 31, 25 |
| 10 | William Blair Investment Management, LLC | 10.63M (3.41%) | -5.12M Decreased by -48.19% | Dec 31, 25 |
| 11 | Redmile Group, LLC | 9.53M (3.06%) | 2.48M Increased by +26.00% | Mar 31, 25 |
| 12 | Geode Capital Management, LLC | 7.35M (2.36%) | 246.17K Increased by +3.35% | Dec 31, 25 |
| 13 | Point72 Asset Management, L.P. | 7.16M (2.30%) | 3.88M Increased by +54.18% | Sep 30, 25 |
| 14 | Bank of America Corp | 7.11M (2.28%) | 261.80K Increased by +3.68% | Sep 30, 25 |
| 15 | Perceptive Advisors LLC | 6.37M (2.05%) | -1.04M Decreased by -16.36% | Sep 30, 25 |
| 16 | D. E. Shaw & Co LP | 6.36M (2.04%) | 4.07M Increased by +64.00% | Jun 30, 25 |
| 17 | Fiera Capital Corporation | 5.28M (1.70%) | 58.11K Increased by +1.10% | Jun 30, 24 |
| 18 | Soleus Capital Management, L.P. | 5.21M (1.67%) | 517.28K Increased by +9.93% | Dec 31, 25 |
| 19 | Palo Alto Investors, LLC | 5.21M (1.67%) | -162.03K Decreased by -3.11% | Dec 31, 25 |
| 20 | Balyasny Asset Management LLC | 5.12M (1.65%) | 3.75M Increased by +73.13% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 20.89M (6.71%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 9.78M (3.14%) | 18.69K Increased by +0.19% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 9.38M (3.01%) | 10.28K Increased by +0.11% | Sep 30, 24 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 8.26M (2.65%) | 45.50K Increased by +0.55% | Feb 28, 26 |
| 5 | iShares Russell 2000 ETF | 7.25M (2.33%) | 1.29M Increased by +17.84% | Feb 28, 26 |
| 6 | Vanguard Small Cap Index | 7.01M (2.25%) | 21.82K Increased by +0.31% | Feb 28, 26 |
| 7 | BlackRock Event Driven Equity Instl | 6.08M (1.95%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 8 | Macquarie Small Cap Core I | 5.62M (1.80%) | 614.64K Increased by +10.94% | Jun 30, 25 |
| 9 | Delaware US Small Cap Core Equity (SMA) | 5.30M (1.70%) | -62.03K Decreased by -1.17% | Mar 31, 24 |
| 10 | Macquarie US Small Cap Core Equity | 5.30M (1.70%) | -62.03K Decreased by -1.17% | Mar 31, 24 |
| 11 | Delaware Small Cap Core I | 5.13M (1.65%) | -31.80K Decreased by -0.62% | Sep 30, 24 |
| 12 | SPDR® S&P Biotech ETF | 5.07M (1.63%) | 151.29K Increased by +2.99% | Jul 31, 25 |
| 13 | Janus Henderson Opportunistic Alpha MA | 4.58M (1.47%) | 4.58M Increased by +99.99% | Jun 30, 24 |
| 14 | Janus Henderson US Opportunistic Alpha | 4.58M (1.47%) | -565.02K Decreased by -12.34% | Jun 30, 24 |
| 15 | Vanguard Small Cap Growth Index Inv | 3.89M (1.25%) | 5.48K Increased by +0.14% | Feb 28, 26 |
| 16 | American Century Heritage Inv | 3.49M (1.12%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 17 | American Century US Opport. Mid Cap Gr | 3.49M (1.12%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 18 | Vanguard Institutional Extnd Mkt Idx Tr | 3.36M (1.08%) | 27.25K Increased by +0.81% | Feb 28, 26 |
| 19 | JPM Global Healthcare C (acc) USD | 3.27M (1.05%) | 0.00 Increased by 0.00% | Jan 31, 24 |
| 20 | Nomura Small Cap Core I | 3.00M (0.96%) | -807.53K Decreased by -26.90% | Jan 31, 26 |