| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | RA Capital Management, LLC | 5.65M (16.03%) | 1.09M Increased by +19.28% | Dec 31, 25 |
| 2 | Bvf Inc | 4.63M (13.13%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Goldman Sachs Group Inc | 4.16M (11.80%) | -9.13K Decreased by -0.22% | Jun 30, 25 |
| 4 | The Goldman Sachs Group Inc | 4.13M (11.71%) | -30.85K Decreased by -0.75% | Sep 30, 25 |
| 5 | BlackRock Inc | 3.87M (10.97%) | -141.63K Decreased by -3.66% | Sep 30, 25 |
| 6 | Novo A/S | 3.65M (10.35%) | 1.65M Increased by +45.22% | Dec 31, 25 |
| 7 | Vanguard Group Inc | 3.09M (8.77%) | 518.40K Increased by +16.76% | Dec 31, 25 |
| 8 | Viking Global Investors LP | 2.93M (8.32%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 9 | State Street Corporation | 2.18M (6.18%) | 654.24K Increased by +30.04% | Mar 31, 24 |
| 10 | Armistice Capital, LLC | 1.94M (5.49%) | 840.00K Increased by +43.39% | Dec 31, 25 |
| 11 | HHG PLC | 1.75M (4.97%) | -1.04K Decreased by -0.06% | Sep 30, 25 |
| 12 | Federated Hermes Inc | 1.59M (4.52%) | -72.51K Decreased by -4.55% | Sep 30, 25 |
| 13 | Point72 Asset Management, L.P. | 1.54M (4.37%) | 1.54M Increased by +100.00% | Dec 31, 25 |
| 14 | Adage Capital Partners Gp LLC | 1.24M (3.50%) | 1.06M Increased by +85.83% | Dec 31, 25 |
| 15 | BRAIDWELL LP | 1.23M (3.48%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 16 | Casdin Capital, LLC | 1.15M (3.26%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 17 | Millennium Management LLC | 1.15M (3.26%) | -334.32K Decreased by -29.09% | Sep 30, 25 |
| 18 | JPMorgan Chase & Co | 1.03M (2.91%) | 139.01K Increased by +13.54% | Sep 30, 25 |
| 19 | FMR Inc | 1.02M (2.88%) | 47.34K Increased by +4.66% | Jun 30, 24 |
| 20 | Geode Capital Management, LLC | 1.01M (2.87%) | 98.51K Increased by +9.73% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.71M (4.84%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 1.54M (4.36%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | State Street® SPDR® S&P® Biotech ETF | 1.39M (3.94%) | 7.70K Increased by +0.55% | Feb 28, 26 |
| 4 | SPDR® S&P Biotech ETF | 990.08K (2.81%) | -30.06K Decreased by -3.04% | Nov 27, 24 |
| 5 | iShares Russell 2000 ETF | 976.61K (2.77%) | 351.15K Increased by +35.96% | Feb 28, 26 |
| 6 | Janus Henderson Gbl Life Sciences Divers | 851.19K (2.41%) | 851.19K Increased by +100.00% | Sep 30, 25 |
| 7 | Janus Henderson Global Life Sciences | 842.52K (2.39%) | -8.67K Decreased by -1.03% | Dec 31, 25 |
| 8 | Janus Henderson Global Life Sciences D | 840.16K (2.38%) | -2.36K Decreased by -0.28% | Jan 31, 26 |
| 9 | Polar Capital Healthcare Opports Inc | 790.16K (2.24%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 10 | Janus Henderson Glb Life Scn I2 USD | 760.51K (2.16%) | 16.11K Increased by +2.12% | Jan 31, 26 |
| 11 | Federated Hermes MDT SCC Institutional | 751.89K (2.13%) | -340.03K Decreased by -45.22% | Dec 31, 25 |
| 12 | Federated Hermes MDT Small Cap Core IS | 751.89K (2.13%) | -340.03K Decreased by -45.22% | Dec 31, 25 |
| 13 | Polar Capital Biotech S Inc | 750.00K (2.13%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 14 | Janus Selection Global Life Science AUSD | 744.60K (2.11%) | -46.09K Decreased by -6.19% | Jun 30, 24 |
| 15 | Janus Global Life Science AUSD | 744.40K (2.11%) | 42.23K Increased by +5.67% | Dec 31, 25 |
| 16 | Janus Henderson Hrzn Biotec E2 USD | 648.77K (1.84%) | 648.77K Increased by +100.00% | Dec 31, 25 |
| 17 | Vanguard Institutional Extnd Mkt Idx Tr | 477.63K (1.35%) | -845.00 Decreased by -0.18% | Feb 28, 26 |
| 18 | Fidelity Growth Compy Commingled Pl O | 469.24K (1.33%) | 521.00 Increased by +0.11% | Jun 30, 24 |
| 19 | Eventide Healthcare & Life Sciences I | 422.86K (1.20%) | -458.30K Decreased by -108.38% | Sep 30, 24 |
| 20 | Federated Hermes MDT SCG Institutional | 395.40K (1.12%) | 119.92K Increased by +30.33% | Jun 30, 25 |