| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Redmile Group, LLC | 12.87M (12.67%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | BlackRock Inc | 10.68M (10.51%) | -129.75K Decreased by -1.21% | Sep 30, 25 |
| 3 | Vanguard Group Inc | 8.97M (8.83%) | 172.86K Increased by +1.93% | Dec 31, 25 |
| 4 | Wilshire Advisors | 8.49M (8.35%) | 8.49M Increased by +100.00% | Sep 30, 25 |
| 5 | State Street Corporation | 8.04M (7.91%) | 6.17M Increased by +76.83% | Mar 31, 24 |
| 6 | Deep Track Capital, LP | 5.57M (5.48%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 7 | Boxer Capital LLC | 4.96M (4.88%) | -3.25M Decreased by -65.61% | Sep 30, 24 |
| 8 | Bellevue Group AG | 4.84M (4.76%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 9 | Deerfield Management Co | 3.56M (3.50%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 10 | JPMorgan Chase & Co | 3.40M (3.34%) | 1.73M Increased by +50.87% | Mar 31, 25 |
| 11 | Johnson & Johnson | 3.38M (3.33%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 12 | EcoR1 Capital, LLC | 3.05M (3.00%) | 3.05M Increased by +100.00% | Dec 31, 24 |
| 13 | Acadian Asset Management LLC | 2.71M (2.67%) | 2.69M Increased by +99.39% | Sep 30, 25 |
| 14 | Suvretta Capital Management, LLC | 2.56M (2.52%) | 2.56M Increased by +100.00% | Mar 31, 24 |
| 15 | Holocene Advisors, LP | 2.53M (2.49%) | 2.53M Increased by +100.00% | Mar 31, 24 |
| 16 | Goldman Sachs Group Inc | 2.51M (2.47%) | 52.70K Increased by +2.10% | Jun 30, 25 |
| 17 | Baker Bros Advisors LP | 2.49M (2.45%) | -773.38K Decreased by -31.12% | Jun 30, 25 |
| 18 | Geode Capital Management, LLC | 2.47M (2.43%) | -61.86K Decreased by -2.51% | Dec 31, 25 |
| 19 | Assenagon Asset Management SA | 2.43M (2.40%) | -140.50K Decreased by -5.77% | Sep 30, 24 |
| 20 | State Street Corp | 2.42M (2.38%) | 188.01K Increased by +7.78% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BB Biotech AG Ord | 4.84M (4.76%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 2 | Vanguard US Total Market Shares ETF | 3.05M (3.00%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.97M (2.93%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | iShares Russell 2000 ETF | 2.63M (2.59%) | 830.98K Increased by +31.62% | Feb 28, 26 |
| 5 | Vanguard Strategic Equity Inv | 2.54M (2.50%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 6 | SPDR® S&P Biotech ETF | 2.35M (2.31%) | -71.37K Decreased by -3.04% | Nov 27, 24 |
| 7 | Vanguard Explorer Inv | 1.27M (1.25%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 8 | Vanguard Small Cap Index | 1.08M (1.06%) | 3.34K Increased by +0.31% | Nov 30, 23 |
| 9 | Vanguard Institutional Extnd Mkt Idx Tr | 1.07M (1.05%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 10 | Fidelity Small Cap Index | 1.06M (1.04%) | 21.38K Increased by +2.01% | Dec 31, 25 |
| 11 | iShares Russell 2000 Value ETF | 909.82K (0.90%) | 909.82K Increased by +100.00% | Feb 28, 26 |
| 12 | BlackRock Advantage Small Cap Core Instl | 887.18K (0.87%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 13 | Fidelity® Small Cap Index | 812.70K (0.80%) | 13.38K Increased by +1.65% | Oct 31, 23 |
| 14 | Bruce | 729.19K (0.72%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | Biotech Growth Ord | 687.00K (0.68%) | 0.00 Increased by 0.00% | May 31, 25 |
| 16 | JPMorgan US Small Company L | 673.58K (0.66%) | -516.65K Decreased by -76.70% | Apr 30, 25 |
| 17 | Federated Hermes MDT SCC Institutional | 666.78K (0.66%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 18 | State St Russell Sm/Mid Cp® Indx NL Cl C | 638.96K (0.63%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 19 | State St Russell Sm/Mid Cp® Indx SL Cl I | 638.96K (0.63%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 20 | T. Rowe Price Health Sciences | 635.97K (0.63%) | -18.05K Decreased by -2.84% | Sep 30, 23 |