| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Orbimed Advisors, LLC | 15.52M (22.96%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | RA Capital Management, LLC | 10.43M (15.43%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | Baker Bros Advisors LP | 6.58M (9.73%) | -730.00K Decreased by -11.10% | Dec 31, 25 |
| 4 | Paradigm Biocapital Advisors LP | 6.54M (9.68%) | 371.08K Increased by +5.67% | Dec 31, 25 |
| 5 | BlackRock Inc | 6.35M (9.40%) | -429.56K Decreased by -6.76% | Sep 30, 25 |
| 6 | Novo A/S | 5.35M (7.91%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | BRAIDWELL LP | 5.21M (7.71%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 8 | HHG PLC | 4.98M (7.37%) | -524.02K Decreased by -10.52% | Sep 30, 25 |
| 9 | Vanguard Group Inc | 4.87M (7.21%) | 67.68K Increased by +1.39% | Dec 31, 25 |
| 10 | FMR Inc | 4.78M (7.07%) | -1.59M Decreased by -33.16% | Jun 30, 24 |
| 11 | Siren, L.L.C. | 4.53M (6.70%) | 632.89K Increased by +13.97% | Dec 31, 25 |
| 12 | Driehaus Capital Management LLC | 4.19M (6.20%) | 1.96M Increased by +46.83% | Dec 31, 25 |
| 13 | Perceptive Advisors LLC | 3.80M (5.62%) | -844.05K Decreased by -22.24% | Sep 30, 25 |
| 14 | Cormorant Asset Management, LLC | 3.29M (4.86%) | -725.00K Decreased by -22.07% | Dec 31, 25 |
| 15 | Citadel Advisors Llc | 2.35M (3.48%) | -418.26K Decreased by -17.80% | Jun 30, 24 |
| 16 | TCG Crossover Management, LLC | 2.11M (3.13%) | -159.74K Decreased by -7.56% | Sep 30, 24 |
| 17 | Deerfield Management Co | 2.07M (3.06%) | -11.19K Decreased by -0.54% | Jun 30, 25 |
| 18 | VR Adviser, LLC | 1.82M (2.69%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 19 | Geode Capital Management, LLC | 1.75M (2.58%) | 28.58K Increased by +1.64% | Dec 31, 25 |
| 20 | State Street Corp | 1.70M (2.51%) | -81.59K Decreased by -4.80% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 2.85M (4.21%) | 6.39K Increased by +0.22% | Feb 28, 26 |
| 2 | BB Biotech AG Ord | 2.78M (4.11%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 3 | Vanguard US Total Market Shares ETF | 2.54M (3.75%) | -5.23K Decreased by -0.21% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 1.64M (2.42%) | 898.67K Increased by +54.90% | Feb 28, 26 |
| 5 | Fidelity® Small Cap Growth | 1.34M (1.99%) | -1.63K Decreased by -0.12% | Oct 31, 23 |
| 6 | Fidelity® Series Small Cap Opps | 1.27M (1.88%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 7 | Fidelity Small Cap Growth | 983.35K (1.45%) | -284.60K Decreased by -28.94% | Jul 31, 24 |
| 8 | Polar Capital Biotech S Inc | 975.00K (1.44%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 9 | Artisan International Small-Mid Investor | 914.19K (1.35%) | 281.23K Increased by +30.76% | Jun 30, 25 |
| 10 | Artisan Non-U.S. Small-Mid Growth Comp | 914.19K (1.35%) | 281.23K Increased by +30.76% | Jun 30, 25 |
| 11 | American Century Small Cap Growth Inv | 873.32K (1.29%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | American Century U.S. Small Cap Growth | 873.32K (1.29%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 13 | Fidelity Select Biotechnology | 817.34K (1.21%) | 222.10K Increased by +27.17% | Jan 31, 26 |
| 14 | Vanguard Institutional Extnd Mkt Idx Tr | 807.94K (1.20%) | 8.82K Increased by +1.09% | Feb 28, 26 |
| 15 | Fidelity® Stock Selector Small Cap | 673.85K (1.00%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 16 | Victory Pioneer Select Mid Cap Growth A | 666.16K (0.99%) | -2.81K Decreased by -0.42% | Jan 31, 26 |
| 17 | Fidelity Small Cap Index | 662.05K (0.98%) | -20.60K Decreased by -3.11% | Dec 31, 25 |
| 18 | Janus Henderson Global Life Sciences D | 628.94K (0.93%) | 11.31K Increased by +1.80% | Jan 31, 26 |
| 19 | Janus Henderson Global Life Sciences | 617.63K (0.91%) | -107.37K Decreased by -17.38% | Dec 31, 25 |
| 20 | Janus Henderson Glb Life Scn I2 USD | 572.80K (0.85%) | 37.30K Increased by +6.51% | Jan 31, 26 |