| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 22.73M (10.14%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | T. Rowe Price Investment Management,Inc. | 20.90M (9.32%) | 666.33K Increased by +3.19% | Dec 31, 25 |
| 3 | VR Adviser, LLC | 17.86M (7.97%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 4 | BlackRock Inc | 15.07M (6.72%) | -94.88K Decreased by -0.63% | Sep 30, 25 |
| 5 | Suvretta Capital Management, LLC | 14.50M (6.47%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 6 | Paradigm Biocapital Advisors LP | 14.16M (6.32%) | 599.08K Increased by +4.23% | Dec 31, 25 |
| 7 | Logos Global Management LP | 13.00M (5.80%) | -2.15M Decreased by -16.54% | Dec 31, 25 |
| 8 | Vanguard Group Inc | 12.81M (5.72%) | 324.00 Increased by +0.00% | Dec 31, 25 |
| 9 | ARCH VENTURE CORP | 11.06M (4.93%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | Cormorant Asset Management, LLC | 10.81M (4.82%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 11 | Vivo Capital, LLC | 9.27M (4.14%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 12 | Siren, L.L.C. | 8.76M (3.91%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 13 | Armistice Capital, LLC | 6.17M (2.75%) | -1.92M Decreased by -31.17% | Mar 31, 24 |
| 14 | 5AM Venture Management, LLC | 5.41M (2.41%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 15 | Octagon Capital Advisors LP | 5.14M (2.29%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 16 | Geode Capital Management, LLC | 4.93M (2.20%) | 77.77K Increased by +1.58% | Dec 31, 25 |
| 17 | Artal Group S A | 4.72M (2.11%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 18 | Citadel Advisors Llc | 4.29M (1.91%) | -27.30K Decreased by -0.64% | Dec 31, 24 |
| 19 | HHG PLC | 4.11M (1.83%) | -4.07M Decreased by -99.00% | Sep 30, 24 |
| 20 | State Street Corp | 4.03M (1.80%) | 27.15K Increased by +0.67% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 8.21M (3.66%) | 16.14K Increased by +0.20% | Feb 28, 26 |
| 2 | T. Rowe Price Small-Cap Value | 4.28M (1.91%) | -5.86K Decreased by -0.14% | Jan 31, 26 |
| 3 | T. Rowe Price Small-Cap Stock | 4.23M (1.89%) | 1.20M Increased by +28.48% | Jan 31, 26 |
| 4 | iShares Russell 2000 ETF | 4.21M (1.88%) | 2.91M Increased by +68.97% | Feb 28, 26 |
| 5 | T. Rowe Price US Small-Cap Core Equity | 3.02M (1.35%) | -539.35K Decreased by -17.83% | Dec 31, 25 |
| 6 | T. Rowe Price U.S. SC Value Eq Tr-Z | 2.91M (1.30%) | 147.12K Increased by +5.05% | Mar 31, 25 |
| 7 | T. Rowe Price U.S. SC Value Eq Tr-D | 2.87M (1.28%) | -1.26M Decreased by -43.92% | Dec 31, 25 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 2.57M (1.15%) | 21.81K Increased by +0.85% | Feb 28, 26 |
| 9 | T. Rowe Price Instl Small-Cap Stock | 2.31M (1.03%) | 611.87K Increased by +26.45% | Jan 31, 26 |
| 10 | SPDR® S&P Biotech ETF | 2.23M (0.99%) | -13.57K Decreased by -0.61% | Feb 28, 25 |
| 11 | State Street® SPDR® S&P® Biotech ETF | 2.18M (0.97%) | 12.10K Increased by +0.55% | Feb 28, 26 |
| 12 | T. Rowe Price US Smlr Coms Eq A | 2.13M (0.95%) | 572.40K Increased by +26.93% | Jan 31, 26 |
| 13 | International Biotechnology Ord | 1.93M (0.86%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 14 | T. Rowe Price U.S. SC Core Eq Tr-Z | 1.82M (0.81%) | 27.83K Increased by +1.53% | Mar 31, 25 |
| 15 | Fidelity Small Cap Index | 1.71M (0.76%) | -71.21K Decreased by -4.17% | Dec 31, 25 |
| 16 | iShares Russell 2000 Value ETF | 1.49M (0.67%) | 858.96K Increased by +57.57% | Feb 28, 26 |
| 17 | T. Rowe Price U.S. SC Core Eq Tr-D | 1.40M (0.62%) | -259.03K Decreased by -18.56% | Dec 31, 25 |
| 18 | T. Rowe Price US Smlr Cm Eq A USD | 1.35M (0.60%) | -69.10K Decreased by -5.13% | Apr 30, 25 |
| 19 | Fidelity Extended Market Index | 1.23M (0.55%) | 100.32K Increased by +8.16% | Jan 31, 26 |
| 20 | iShares Biotechnology ETF | 1.19M (0.53%) | 0.00 Increased by 0.00% | Feb 28, 26 |