| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Nantahala Capital Management, LLC | 5.82M (11.98%) | 93.79K Increased by +1.61% | Dec 31, 25 |
| 2 | BlackRock Inc | 4.48M (9.21%) | 292.63K Increased by +6.54% | Sep 30, 25 |
| 3 | Caligan Partners LP | 4.14M (8.52%) | 796.97K Increased by +19.26% | Sep 30, 25 |
| 4 | Vanguard Group Inc | 3.34M (6.88%) | -87.14K Decreased by -2.61% | Dec 31, 25 |
| 5 | BRAIDWELL LP | 3.11M (6.39%) | 3.11M Increased by +100.00% | Dec 31, 25 |
| 6 | Frazier Life Sciences Management, L.P. | 2.63M (5.41%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | Perceptive Advisors LLC | 2.47M (5.09%) | -1.65M Decreased by -66.84% | Jun 30, 25 |
| 8 | First Manhattan Co. LLC | 2.29M (4.71%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 9 | Millennium Management LLC | 2.09M (4.31%) | 234.03K Increased by +11.18% | Dec 31, 25 |
| 10 | Frontier Capital Management CO Inc | 1.66M (3.43%) | 457.53K Increased by +27.48% | Jun 30, 25 |
| 11 | Stonepine Capital Management Llc | 1.63M (3.36%) | 95.20K Increased by +5.83% | Dec 31, 25 |
| 12 | D. E. Shaw & Co LP | 1.54M (3.17%) | 186.70K Increased by +12.11% | Dec 31, 25 |
| 13 | State Street Corp | 1.52M (3.12%) | 108.62K Increased by +7.17% | Sep 30, 25 |
| 14 | Eversept Partners, LP | 1.48M (3.04%) | 304.80K Increased by +20.66% | Sep 30, 25 |
| 15 | Geode Capital Management, LLC | 1.39M (2.85%) | -30.94K Decreased by -2.23% | Dec 31, 25 |
| 16 | Citadel Advisors Llc | 1.38M (2.84%) | 790.72K Increased by +57.33% | Dec 31, 25 |
| 17 | TANG CAPITAL MANAGEMENT LLC | 1.25M (2.56%) | -4.24M Decreased by -340.58% | Dec 31, 25 |
| 18 | Eversept Partners, LLC | 1.17M (2.41%) | 1.17M Increased by +100.00% | Jun 30, 25 |
| 19 | Rice Hall James & Associates, LLC | 1.15M (2.37%) | -15.44K Decreased by -1.34% | Dec 31, 25 |
| 20 | BOOTHBAY FUND MANAGEMENT, LLC | 1.14M (2.35%) | -146.54K Decreased by -12.84% | Mar 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 5.66M (11.65%) | -99.14K Decreased by -1.75% | Dec 31, 24 |
| 2 | Vanguard US Total Market Shares ETF | 1.68M (3.47%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.67M (3.43%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | iShares Russell 2000 ETF | 1.31M (2.69%) | 565.53K Increased by +43.32% | Feb 28, 26 |
| 5 | Xtrackers S&P 500 Swap ETF 1C | 731.43K (1.51%) | 0.00 Increased by 0.00% | Jun 30, 24 |
| 6 | Vanguard Institutional Extnd Mkt Idx Tr | 728.47K (1.50%) | 11.00K Increased by +1.51% | Feb 28, 26 |
| 7 | Schroder US Smaller Companies Acc | 718.22K (1.48%) | -15.14K Decreased by -2.11% | Dec 31, 25 |
| 8 | Oberweis Micro-Cap | 677.60K (1.39%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 9 | Oberweis Micro-Cap Growth | 677.60K (1.39%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 10 | CREF Stock R1 | 572.75K (1.18%) | 245.42K Increased by +42.85% | Feb 28, 25 |
| 11 | Fidelity Small Cap Index | 509.19K (1.05%) | -85.73K Decreased by -16.84% | Dec 31, 25 |
| 12 | State Street® SPDR® S&P® PhrmctlsETF | 475.88K (0.98%) | 4.14K Increased by +0.87% | Feb 28, 26 |
| 13 | Invesco S&P 500 ETF | 468.69K (0.96%) | 468.69K Increased by +100.00% | Jul 31, 25 |
| 14 | Nuveen Quant Small Cap Equity Instl | 463.37K (0.95%) | 9.34K Increased by +2.02% | Feb 29, 24 |
| 15 | Nuveen Quant Small Cap Equity R6 | 456.83K (0.94%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 16 | TIAA-CREF Quant Small-Cap Equity Instl | 454.03K (0.93%) | 0.00 Increased by 0.00% | Dec 31, 23 |
| 17 | iShares Russell 2000 Growth ETF | 433.24K (0.89%) | 83.49K Increased by +19.27% | Feb 28, 26 |
| 18 | Frontier Small Cap Growth | 429.44K (0.88%) | -30.89K Decreased by -7.19% | Jun 30, 25 |
| 19 | Fidelity® Small Cap Index | 401.19K (0.83%) | 11.60K Increased by +2.89% | Oct 31, 23 |
| 20 | Xtrackers MSCI World Swap ETF 1C | 393.42K (0.81%) | -2.48K Decreased by -0.63% | Dec 31, 25 |