| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 9.00M (13.10%) | -828.98K Decreased by -9.21% | Sep 30, 25 |
| 2 | Atlas Venture Life Science Advisors, LLC | 6.41M (9.33%) | -17.70K Decreased by -0.28% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 6.28M (9.15%) | 101.05K Increased by +1.61% | Dec 31, 25 |
| 4 | RA Capital Management, LLC | 5.76M (8.38%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 5 | FMR Inc | 5.72M (8.32%) | -4.38M Decreased by -76.63% | Dec 31, 25 |
| 6 | Vestal Point Capital LP | 5.20M (7.57%) | 2.52M Increased by +48.56% | Dec 31, 25 |
| 7 | Deerfield Management Co | 3.72M (5.42%) | -982.28K Decreased by -26.38% | Dec 31, 25 |
| 8 | Franklin Resources Inc | 3.48M (5.06%) | -620.60K Decreased by -17.85% | Sep 30, 25 |
| 9 | State Street Corporation | 3.38M (4.92%) | 444.18K Increased by +13.14% | Dec 31, 23 |
| 10 | Estuary Capital Management, LP | 3.33M (4.84%) | -389.93K Decreased by -11.72% | Mar 31, 25 |
| 11 | State Street Corp | 3.24M (4.72%) | 550.76K Increased by +17.00% | Sep 30, 25 |
| 12 | Fairmount Funds Management LLC | 3.10M (4.52%) | 0.00 Increased by 0.00% | Dec 31, 24 |
| 13 | Alyeska Investment Group, L.P. | 3.01M (4.38%) | -1.05M Decreased by -34.78% | Jun 30, 25 |
| 14 | Pictet Asset Manangement SA | 2.99M (4.35%) | 617.67K Increased by +20.65% | Dec 31, 25 |
| 15 | Viking Global Investors LP | 2.56M (3.72%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 16 | Canaan Partners XI LLC | 2.49M (3.63%) | -56.84K Decreased by -2.28% | Sep 30, 23 |
| 17 | Partner Fund Management LP | 2.22M (3.24%) | 1.08M Increased by +48.43% | Sep 30, 23 |
| 18 | Wagonhound Investments, LP | 2.19M (3.19%) | -48.46K Decreased by -2.21% | Sep 30, 23 |
| 19 | BRAIDWELL LP | 2.18M (3.18%) | -1.36M Decreased by -62.12% | Jun 30, 25 |
| 20 | Maverick Capital Ltd | 2.11M (3.08%) | 902.87K Increased by +42.71% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | State Street® SPDR® S&P® Biotech ETF | 2.61M (3.80%) | 14.49K Increased by +0.55% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 2.46M (3.58%) | 522.40K Increased by +21.25% | Sep 30, 24 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 2.41M (3.51%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | Polar Capital Biotech S Inc | 2.11M (3.07%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 5 | Pictet-Biotech P USD | 1.91M (2.77%) | 575.67K Increased by +30.20% | Nov 30, 25 |
| 6 | iShares Russell 2000 ETF | 1.90M (2.76%) | 1.41M Increased by +74.13% | Feb 28, 26 |
| 7 | Franklin Small Cap Growth SMA | 1.61M (2.35%) | 1.61M Increased by +99.99% | Jun 30, 25 |
| 8 | Franklin US Small Cap Growth Equity | 1.61M (2.35%) | 130.60K Increased by +8.10% | Jun 30, 25 |
| 9 | Franklin Biotechnology Discv A(acc)USD | 1.55M (2.26%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 10 | FIAM Small Cap Core Composite | 1.55M (2.25%) | 226.95K Increased by +14.66% | Sep 30, 25 |
| 11 | Franklin Small Cap Growth Adv | 1.48M (2.16%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 12 | FIAM Small Cap Core CIT Cl B | 1.38M (2.01%) | -5.50K Decreased by -0.40% | Dec 31, 25 |
| 13 | Pictet Biotech | 1.37M (2.00%) | 1.37M Increased by +100.00% | Mar 31, 24 |
| 14 | SPDR® S&P Biotech ETF | 1.20M (1.75%) | 2.69K Increased by +0.22% | Aug 31, 25 |
| 15 | Fidelity Growth Compy Commingled Pl S | 1.15M (1.68%) | 4.03K Increased by +0.35% | Jan 31, 26 |
| 16 | US Small-Cap Growth II Equity Comp | 1.14M (1.67%) | -397.68K Decreased by -34.74% | Dec 31, 24 |
| 17 | Fidelity Select Health Care | 1.00M (1.46%) | 0.00 Increased by 0.00% | Jul 31, 25 |
| 18 | T. Rowe Price New Horizons | 980.72K (1.43%) | 0.00 Increased by 0.00% | Feb 28, 25 |
| 19 | Fidelity Stock Selector Small Cap | 936.00K (1.36%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 20 | Vanguard Small Cap Index | 875.84K (1.27%) | 1.85K Increased by +0.21% | Feb 28, 26 |