| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Avidity Partners Management LP | 6.36M (6.89%) | 310.00K Increased by +4.87% | Dec 31, 23 |
| 2 | State Street Corporation | 5.12M (5.55%) | -233.72K Decreased by -4.57% | Dec 31, 23 |
| 3 | Pfizer Inc | 4.69M (5.08%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 4 | Vanguard Group Inc | 4.30M (4.66%) | 77.27K Increased by +1.80% | Dec 31, 25 |
| 5 | Deerfield Management Co | 3.50M (3.79%) | 3.50M Increased by +100.00% | Sep 30, 23 |
| 6 | Alkeon Capital Management, LLC | 3.11M (3.37%) | 1.47M Increased by +47.17% | Dec 31, 23 |
| 7 | Paradigm Biocapital Advisors LP | 2.92M (3.17%) | -20.66K Decreased by -0.71% | Dec 31, 23 |
| 8 | Morgan Stanley - Brokerage Accounts | 2.75M (2.98%) | 1.55M Increased by +56.42% | Dec 31, 24 |
| 9 | Rokos Capital Management LLP | 2.75M (2.98%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 10 | Assenagon Asset Management SA | 2.65M (2.87%) | 1.89M Increased by +71.23% | Sep 30, 23 |
| 11 | Kynam Capital Management, LP | 2.50M (2.71%) | -564.47K Decreased by -22.55% | Dec 31, 25 |
| 12 | Schonfeld Strategic Advisors LLC | 2.27M (2.46%) | -78.72K Decreased by -3.46% | Jun 30, 25 |
| 13 | Elmwood Wealth Management, Inc. | 2.03M (2.20%) | -150.00K Decreased by -7.40% | Dec 31, 24 |
| 14 | State Street Corp | 1.64M (1.78%) | -16.38K Decreased by -1.00% | Mar 31, 25 |
| 15 | Renaissance Technologies Corp | 1.64M (1.78%) | 859.44K Increased by +52.41% | Dec 31, 25 |
| 16 | BlackRock Inc | 1.46M (1.58%) | -424.16K Decreased by -29.07% | Sep 30, 25 |
| 17 | Aberdeen Group PLC | 1.39M (1.51%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 18 | Woodline Partners LP | 1.14M (1.24%) | 679.13K Increased by +59.54% | Dec 31, 23 |
| 19 | Two Sigma Advisers, LLC | 1.12M (1.21%) | -111.70K Decreased by -10.01% | Dec 31, 25 |
| 20 | Bank of America Corp | 1.07M (1.16%) | 265.54K Increased by +24.71% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | SPDR® S&P Biotech ETF | 4.54M (4.92%) | 24.19K Increased by +0.53% | Mar 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 2.73M (2.96%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | ACATIS Datini Valueflex Fonds A | 2.00M (2.17%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 4 | Selectra J. Lamarck Biotech A | 1.65M (1.79%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 5 | abrdn Life Sciences Investors | 1.21M (1.31%) | -176.36K Decreased by -14.54% | Feb 28, 26 |
| 6 | Belfius Equities Cure C Cap | 1.15M (1.24%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 7 | Pictet-Biotech P USD | 1.09M (1.18%) | -241.00K Decreased by -22.12% | Jun 30, 23 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 925.03K (1.00%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 9 | Candriam Global Equities Oncology | 860.00K (0.93%) | 360.00K Increased by +41.86% | Dec 31, 23 |
| 10 | Fidelity Small Cap Index | 843.92K (0.91%) | 0.00 Increased by 0.00% | May 31, 25 |
| 11 | iShares Russell 2000 Value ETF | 762.12K (0.83%) | 0.00 Increased by 0.00% | May 31, 25 |
| 12 | Fidelity® Small Cap Index | 724.39K (0.79%) | 22.01K Increased by +3.04% | Oct 31, 23 |
| 13 | Pictet-Global Megatrend Sel I USD | 672.75K (0.73%) | 1.38K Increased by +0.20% | Dec 31, 23 |
| 14 | iShares Biotechnology ETF | 621.68K (0.67%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 15 | Direxion Daily S&P Biotech Bull 3X ETF | 541.45K (0.59%) | -3.80K Decreased by -0.70% | Mar 31, 24 |
| 16 | State St Russell Sm/Mid Cp® Indx NL Cl C | 478.79K (0.52%) | 0.00 Increased by 0.00% | Apr 30, 25 |
| 17 | State St Russell Sm/Mid Cp® Indx SL Cl I | 478.79K (0.52%) | 0.00 Increased by 0.00% | May 31, 25 |
| 18 | Schwab US Small-Cap ETF™ | 431.93K (0.47%) | 372.00 Increased by +0.09% | Feb 28, 26 |
| 19 | Vanguard Russell 2000 ETF | 411.14K (0.45%) | 3.71K Increased by +0.90% | May 31, 25 |
| 20 | Fidelity® Extended Market Index | 405.44K (0.44%) | 0.00 Increased by 0.00% | Nov 30, 23 |