| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 23.09M (15.29%) | 678.70K Increased by +2.94% | Dec 31, 25 |
| 2 | Vanguard Group Inc | 11.51M (7.63%) | 3.76M Increased by +32.63% | Dec 31, 25 |
| 3 | BlackRock Inc | 10.37M (6.87%) | 1.74M Increased by +16.81% | Sep 30, 25 |
| 4 | Paradigm Biocapital Advisors LP | 10.35M (6.86%) | 1.39M Increased by +13.42% | Jun 30, 25 |
| 5 | Deerfield Management Co | 9.04M (5.99%) | -9.21K Decreased by -0.10% | Dec 31, 25 |
| 6 | Fairmount Funds Management LLC | 9.00M (5.96%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | State Street Corporation | 7.63M (5.05%) | 3.48M Increased by +45.58% | Mar 31, 24 |
| 8 | RTW INVESTMENTS, LLC | 7.59M (5.03%) | 4.12M Increased by +54.33% | Dec 31, 25 |
| 9 | RA Capital Management, LLC | 6.42M (4.25%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 10 | Kynam Capital Management, LP | 6.17M (4.08%) | -1.72M Decreased by -27.91% | Dec 31, 25 |
| 11 | TCG Crossover Management, LLC | 5.87M (3.89%) | -930.00K Decreased by -15.85% | Dec 31, 25 |
| 12 | Point72 Asset Management, L.P. | 4.91M (3.25%) | -383.62K Decreased by -7.81% | Jun 30, 25 |
| 13 | State Street Corp | 4.78M (3.16%) | 1.40M Increased by +29.39% | Sep 30, 25 |
| 14 | Adage Capital Partners Gp LLC | 4.30M (2.85%) | 233.97K Increased by +5.44% | Dec 31, 24 |
| 15 | Suvretta Capital Management, LLC | 3.71M (2.46%) | 657.24K Increased by +17.71% | Dec 31, 23 |
| 16 | UBS Group AG | 3.52M (2.33%) | 414.54K Increased by +11.78% | Jun 30, 25 |
| 17 | Geode Capital Management, LLC | 3.51M (2.33%) | 240.41K Increased by +6.84% | Dec 31, 25 |
| 18 | HHG PLC | 3.18M (2.11%) | 304.99K Increased by +9.60% | Sep 30, 25 |
| 19 | Vestal Point Capital LP | 3.08M (2.04%) | 80.00K Increased by +2.60% | Jun 30, 25 |
| 20 | Wellington Management Company LLP | 2.71M (1.80%) | 2.31M Increased by +85.00% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 4.60M (3.04%) | 28.41K Increased by +0.62% | Feb 28, 26 |
| 2 | iShares Russell 2000 ETF | 3.38M (2.24%) | 2.42M Increased by +71.53% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 3.09M (2.05%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Fidelity Select Health Care | 2.60M (1.72%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 5 | Fidelity Small Cap Growth | 2.51M (1.66%) | -13.16K Decreased by -0.52% | Dec 31, 25 |
| 6 | Fidelity Advisor Biotechnology I | 1.99M (1.32%) | -74.60K Decreased by -3.75% | Jan 31, 26 |
| 7 | FIAM Small Cap Core Composite | 1.87M (1.24%) | 225.12K Increased by +12.06% | Mar 31, 25 |
| 8 | State Street® SPDR® S&P® Biotech ETF | 1.86M (1.23%) | 10.25K Increased by +0.55% | Feb 28, 26 |
| 9 | Fidelity Select Biotechnology | 1.83M (1.22%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 10 | FIAM Small Cap Core CIT Cl B | 1.83M (1.21%) | -15.60K Decreased by -0.85% | May 31, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 1.67M (1.11%) | 15.76K Increased by +0.94% | Feb 28, 26 |
| 12 | Vanguard Small Cap Index | 1.66M (1.10%) | 3.50K Increased by +0.21% | Feb 28, 26 |
| 13 | Fidelity Small Cap Index | 1.36M (0.90%) | -39.01K Decreased by -2.86% | Dec 31, 25 |
| 14 | Fidelity Advisor Health Care I | 1.36M (0.90%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 15 | Lord Abbett Growth Leaders I | 1.27M (0.84%) | 1.27M Increased by +100.00% | Jan 31, 26 |
| 16 | Fidelity Small Cap Growth K6 | 1.25M (0.83%) | -8.09K Decreased by -0.65% | Dec 31, 25 |
| 17 | Fidelity OTC | 1.24M (0.82%) | 368.92K Increased by +29.71% | Jan 31, 26 |
| 18 | Fidelity Advisor® Biotechnology I | 1.20M (0.79%) | 194.20K Increased by +16.20% | Nov 30, 23 |
| 19 | Fidelity Stock Selector Small Cap | 1.14M (0.76%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | Strategic Advisers Fidelity US TtlStk | 1.13M (0.75%) | 0.00 Increased by 0.00% | Jan 31, 26 |