| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | FMR Inc | 17.08M (14.64%) | 1.14K Increased by +0.01% | Jun 30, 25 |
| 2 | Paradigm Biocapital Advisors LP | 10.35M (8.87%) | 1.39M Increased by +13.42% | Jun 30, 25 |
| 3 | BlackRock Inc | 8.63M (7.39%) | 451.05K Increased by +5.23% | Jun 30, 25 |
| 4 | Kynam Capital Management, LP | 8.49M (7.28%) | -612.44K Decreased by -7.21% | Jun 30, 25 |
| 5 | State Street Corporation | 7.63M (6.54%) | 3.48M Increased by +45.58% | Mar 31, 24 |
| 6 | TCG Crossover Management, LLC | 6.96M (5.97%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 7 | Vanguard Group Inc | 6.52M (5.59%) | 464.61K Increased by +7.12% | Jun 30, 25 |
| 8 | RA Capital Management, LLC | 6.42M (5.50%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 9 | Fairmount Funds Management LLC | 6.23M (5.34%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 10 | Point72 Asset Management, L.P. | 4.91M (4.21%) | -383.62K Decreased by -7.81% | Jun 30, 25 |
| 11 | VR Adviser, LLC | 4.76M (4.08%) | -929.00K Decreased by -19.54% | Jun 30, 25 |
| 12 | Adage Capital Partners Gp LLC | 4.30M (3.68%) | 233.97K Increased by +5.44% | Dec 31, 24 |
| 13 | Suvretta Capital Management, LLC | 3.71M (3.18%) | 657.24K Increased by +17.71% | Dec 31, 23 |
| 14 | UBS Group AG | 3.52M (3.02%) | 414.54K Increased by +11.78% | Jun 30, 25 |
| 15 | State Street Corp | 3.37M (2.89%) | -744.88K Decreased by -22.09% | Jun 30, 25 |
| 16 | Redmile Group, LLC | 3.22M (2.76%) | -338.81K Decreased by -10.54% | Mar 31, 25 |
| 17 | Vestal Point Capital LP | 3.08M (2.64%) | 80.00K Increased by +2.60% | Jun 30, 25 |
| 18 | HHG PLC | 2.87M (2.46%) | 2.84M Increased by +98.99% | Jun 30, 25 |
| 19 | Octagon Capital Advisors LP | 2.76M (2.37%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 20 | Geode Capital Management, LLC | 2.67M (2.29%) | 256.26K Increased by +9.59% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 4.06M (3.48%) | 592.96K Increased by +14.59% | Jul 31, 25 |
| 2 | Fidelity Select Health Care | 3.38M (2.90%) | 238.90K Increased by +7.07% | Jul 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 3.09M (2.65%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 4 | Fidelity Advisor Biotechnology I | 2.58M (2.21%) | 581.61K Increased by +22.55% | Jul 31, 25 |
| 5 | Fidelity Small Cap Growth | 2.57M (2.21%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 6 | iShares Russell 2000 ETF | 2.57M (2.20%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 7 | Fidelity Advisor Health Care I | 1.90M (1.63%) | 100.00K Increased by +5.26% | Jul 31, 25 |
| 8 | FIAM Small Cap Core Composite | 1.87M (1.60%) | 225.12K Increased by +12.06% | Mar 31, 25 |
| 9 | FIAM Small Cap Core CIT Cl B | 1.83M (1.56%) | -15.60K Decreased by -0.85% | May 31, 25 |
| 10 | Fidelity Select Biotechnology | 1.57M (1.34%) | 403.00K Increased by +25.72% | Jul 31, 25 |
| 11 | Vanguard Institutional Extnd Mkt Idx Tr | 1.38M (1.19%) | -278.29K Decreased by -20.09% | Jul 31, 25 |
| 12 | Fidelity Stock Selector Small Cap | 1.28M (1.10%) | 51.20K Increased by +4.00% | Jun 30, 25 |
| 13 | Fidelity Advisor® Biotechnology I | 1.20M (1.03%) | 194.20K Increased by +16.20% | Nov 30, 23 |
| 14 | Strategic Advisers Fidelity US TtlStk | 1.18M (1.01%) | 1.00M Increased by +85.05% | Jul 31, 25 |
| 15 | Fidelity Small Cap Growth K6 | 1.16M (0.99%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 16 | Fidelity Series Small Cap Opps | 1.13M (0.97%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 17 | SPDR® S&P Biotech ETF | 1.12M (0.96%) | 2.50K Increased by +0.22% | Aug 31, 25 |
| 18 | Fidelity Small Cap Index | 1.07M (0.91%) | 136.45K Increased by +12.80% | Jun 30, 25 |
| 19 | Fidelity® Series Small Cap Opps | 948.10K (0.81%) | 0.00 Increased by 0.00% | Oct 31, 23 |
| 20 | HBM Healthcare Investments AG Ord | 947.78K (0.81%) | 0.00 Increased by 0.00% | Sep 30, 23 |