| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Baker Bros Advisors LP | 7.92M (26.70%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | NEA Management Company, LLC | 3.54M (11.93%) | 1.39M Increased by +39.35% | Dec 31, 25 |
| 3 | Bvf Inc | 3.47M (11.69%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | venBio Select Advisor LLC | 3.11M (10.49%) | 3.11M Increased by +100.00% | Dec 31, 25 |
| 5 | Perceptive Advisors LLC | 2.96M (9.97%) | 1.32M Increased by +44.76% | Sep 30, 25 |
| 6 | Vanguard Group Inc | 2.28M (7.69%) | 220.39K Increased by +9.67% | Dec 31, 25 |
| 7 | BlackRock Inc | 2.25M (7.58%) | 175.76K Increased by +7.82% | Sep 30, 25 |
| 8 | Soleus Capital Management, L.P. | 1.81M (6.10%) | 629.40K Increased by +34.81% | Dec 31, 25 |
| 9 | Deerfield Management Co | 1.71M (5.78%) | 980.47K Increased by +57.20% | Dec 31, 25 |
| 10 | Morgan Stanley - Brokerage Accounts | 1.51M (5.10%) | 728.77K Increased by +48.17% | Sep 30, 25 |
| 11 | RA Capital Management, LLC | 1.40M (4.72%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 12 | Eventide Asset Management, LLC | 1.39M (4.69%) | 123.77K Increased by +8.91% | Jun 30, 25 |
| 13 | Samlyn Capital, LLC | 1.25M (4.22%) | -39.34K Decreased by -3.14% | Dec 31, 24 |
| 14 | Saturn V Capital Management LLC | 1.19M (4.00%) | 91.84K Increased by +7.75% | Jun 30, 25 |
| 15 | TANG CAPITAL MANAGEMENT LLC | 1.05M (3.54%) | -100.00K Decreased by -9.52% | Dec 31, 25 |
| 16 | VR Adviser, LLC | 970.00K (3.27%) | -1.14M Decreased by -117.05% | Mar 31, 24 |
| 17 | Balyasny Asset Management LLC | 937.79K (3.16%) | 55.85K Increased by +5.96% | Jun 30, 24 |
| 18 | BRAIDWELL LP | 884.31K (2.98%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 19 | UBS Group AG | 854.48K (2.88%) | 769.89K Increased by +90.10% | Sep 30, 25 |
| 20 | Geode Capital Management, LLC | 830.68K (2.80%) | 64.21K Increased by +7.73% | Dec 31, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Total Stock Mkt Idx Inv | 1.33M (4.48%) | 2.67K Increased by +0.20% | Feb 28, 26 |
| 2 | Vanguard US Total Market Shares ETF | 1.00M (3.39%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 3 | State Street® SPDR® S&P® Biotech ETF | 956.60K (3.23%) | 5.28K Increased by +0.55% | Feb 28, 26 |
| 4 | iShares Russell 2000 ETF | 783.54K (2.64%) | 783.54K Increased by +100.00% | Feb 28, 26 |
| 5 | T. Rowe Price Health Sciences | 586.56K (1.98%) | 10.76K Increased by +1.83% | Jan 31, 26 |
| 6 | Columbia Small Cap Value Discovery Fund | 523.74K (1.77%) | 208.46K Increased by +39.80% | Jun 30, 25 |
| 7 | Columbia Small Cap Value I | 523.74K (1.77%) | 208.46K Increased by +39.80% | Jun 30, 25 |
| 8 | Vanguard Institutional Extnd Mkt Idx Tr | 393.38K (1.33%) | 3.24K Increased by +0.82% | Feb 28, 26 |
| 9 | Artisan International Small-Mid Investor | 331.60K (1.12%) | -31.17K Decreased by -9.40% | Dec 31, 25 |
| 10 | Artisan Non-U.S. Small-Mid Growth Comp | 331.60K (1.12%) | -31.17K Decreased by -9.40% | Dec 31, 25 |
| 11 | SPDR® S&P Biotech ETF | 327.79K (1.11%) | -2.00K Decreased by -0.61% | Feb 28, 25 |
| 12 | Fidelity Small Cap Index | 315.46K (1.06%) | 17.57K Increased by +5.57% | Dec 31, 25 |
| 13 | Eventide Healthcare & Life Sciences I | 312.58K (1.05%) | -776.13K Decreased by -248.29% | Dec 31, 25 |
| 14 | Belfius Equities Cure C Cap | 302.31K (1.02%) | -61.87K Decreased by -20.47% | Nov 30, 25 |
| 15 | iShares Russell 2000 Growth ETF | 256.01K (0.86%) | 256.01K Increased by +100.00% | Feb 28, 26 |
| 16 | US Small-Cap Growth II Equity Comp | 197.80K (0.67%) | 197.80K Increased by +100.00% | Dec 31, 25 |
| 17 | T. Rowe Price New Horizons | 197.60K (0.67%) | -202.00 Decreased by -0.10% | Jan 31, 26 |
| 18 | Candriam Eqs L Biotech C USD Cap | 195.99K (0.66%) | 6.12K Increased by +3.12% | Oct 31, 25 |
| 19 | Invesco Dorsey Wright SmallCap Momt ETF | 191.97K (0.65%) | 0.00 Increased by 0.00% | Apr 30, 24 |
| 20 | AB Small Cap Growth A | 188.75K (0.64%) | -11.50K Decreased by -6.09% | Jan 31, 26 |