| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BlackRock Inc | 21.43M (11.84%) | -1.34M Decreased by -6.27% | Jun 30, 25 |
| 2 | Vanguard Group Inc | 20.54M (11.36%) | -1.12M Decreased by -5.43% | Jun 30, 25 |
| 3 | State Street Corporation | 17.48M (9.66%) | 4.70M Increased by +26.89% | Mar 31, 24 |
| 4 | Baker Bros Advisors LP | 10.13M (5.60%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 5 | State Street Corp | 8.51M (4.70%) | 691.99K Increased by +8.14% | Jun 30, 25 |
| 6 | Kynam Capital Management, LP | 8.46M (4.68%) | -464.78K Decreased by -5.49% | Jun 30, 25 |
| 7 | Alkeon Capital Management, LLC | 5.71M (3.16%) | -1.50M Decreased by -26.25% | Jun 30, 25 |
| 8 | UBS Group AG | 5.61M (3.10%) | 3.21M Increased by +57.20% | Jun 30, 25 |
| 9 | Morgan Stanley - Brokerage Accounts | 5.33M (2.95%) | 3.03M Increased by +56.89% | Jun 30, 25 |
| 10 | Geode Capital Management, LLC | 5.05M (2.79%) | 93.97K Increased by +1.86% | Jun 30, 25 |
| 11 | Deerfield Management Co | 4.69M (2.59%) | -497.67K Decreased by -10.61% | Jun 30, 25 |
| 12 | venBio Select Advisor LLC | 4.50M (2.49%) | -4.20M Decreased by -93.33% | Jun 30, 25 |
| 13 | D. E. Shaw & Co LP | 4.39M (2.43%) | 2.80M Increased by +63.80% | Jun 30, 25 |
| 14 | Two Sigma Investments LLC | 4.29M (2.37%) | 2.24M Increased by +52.30% | Jun 30, 25 |
| 15 | Arrowstreet Capital Limited Partnership | 4.28M (2.36%) | 4.08M Increased by +95.46% | Jun 30, 25 |
| 16 | Two Sigma Advisers, LLC | 4.23M (2.34%) | 1.01M Increased by +23.83% | Jun 30, 25 |
| 17 | Pictet Asset Manangement SA | 4.19M (2.32%) | 4.19M Increased by +100.00% | Sep 30, 23 |
| 18 | RP Management, LLC | 3.85M (2.13%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 19 | Millennium Management LLC | 3.81M (2.11%) | 3.02M Increased by +79.28% | Mar 31, 25 |
| 20 | Assenagon Asset Management SA | 3.62M (2.00%) | 3.61M Increased by +99.61% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 17.22M (9.52%) | 17.22M Increased by +100.00% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 6.59M (3.64%) | -139.50K Decreased by -2.12% | Jul 31, 25 |
| 3 | Vanguard US Total Market Shares ETF | 6.57M (3.63%) | -18.55K Decreased by -0.28% | Sep 30, 24 |
| 4 | iShares Russell 2000 ETF | 5.04M (2.79%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 5 | SPDR® S&P Biotech ETF | 3.67M (2.03%) | 8.19K Increased by +0.22% | Aug 31, 25 |
| 6 | ACAP Strategic A | 2.82M (1.56%) | -727.21K Decreased by -25.79% | Jun 30, 25 |
| 7 | Pictet-Biotech P USD | 2.79M (1.54%) | -13.26K Decreased by -0.47% | Jul 31, 23 |
| 8 | Fidelity® Select Biotechnology | 2.58M (1.43%) | -225.50K Decreased by -8.74% | Nov 30, 23 |
| 9 | Vanguard Small Cap Index | 2.54M (1.40%) | -17.21K Decreased by -0.68% | Jul 31, 25 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 2.25M (1.24%) | -987.45K Decreased by -43.93% | Jul 31, 25 |
| 11 | Fidelity Small Cap Index | 2.10M (1.16%) | 5.33K Increased by +0.25% | Jun 30, 25 |
| 12 | Eventide Healthcare & Life Sciences I | 1.97M (1.09%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 13 | iShares Russell 2000 Growth ETF | 1.84M (1.02%) | 0.00 Increased by 0.00% | Aug 31, 25 |
| 14 | Fidelity® Small Cap Index | 1.82M (1.01%) | 49.54K Increased by +2.71% | Oct 31, 23 |
| 15 | Pictet-Global Megatrend Sel I USD | 1.75M (0.97%) | 438.00 Increased by +0.02% | Jul 31, 23 |
| 16 | Vanguard Strategic Equity Inv | 1.74M (0.96%) | -199.07K Decreased by -11.47% | Jun 30, 25 |
| 17 | Invesco S&P 500 ETF | 1.69M (0.93%) | 1.69M Increased by +100.00% | Jul 31, 25 |
| 18 | Vanguard Small Cap Growth Index Inv | 1.44M (0.80%) | -541.00 Decreased by -0.04% | Jul 31, 25 |
| 19 | CREF Stock R3 | 1.31M (0.73%) | 36.26K Increased by +2.76% | Jul 31, 25 |
| 20 | BNP Paribas Health Cr Innovtr Cl Cap | 1.28M (0.71%) | -120.93K Decreased by -9.45% | Nov 30, 23 |