| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 22.27M (10.21%) | 482.49K Increased by +2.17% | Dec 31, 25 |
| 2 | BlackRock Inc | 21.25M (9.74%) | -179.97K Decreased by -0.85% | Sep 30, 25 |
| 3 | State Street Corporation | 17.48M (8.01%) | 4.70M Increased by +26.89% | Mar 31, 24 |
| 4 | RA Capital Management, LLC | 15.83M (7.25%) | 15.83M Increased by +100.00% | Dec 31, 25 |
| 5 | Deerfield Management Co | 14.34M (6.57%) | 2.17M Increased by +15.15% | Dec 31, 25 |
| 6 | State Street Corp | 9.81M (4.50%) | 1.30M Increased by +13.28% | Sep 30, 25 |
| 7 | Kynam Capital Management, LP | 9.37M (4.29%) | -23.74K Decreased by -0.25% | Dec 31, 25 |
| 8 | UBS Group AG | 5.97M (2.74%) | 353.09K Increased by +5.92% | Sep 30, 25 |
| 9 | Alkeon Capital Management, LLC | 5.71M (2.62%) | -1.50M Decreased by -26.25% | Jun 30, 25 |
| 10 | Morgan Stanley - Brokerage Accounts | 5.20M (2.38%) | -126.72K Decreased by -2.44% | Sep 30, 25 |
| 11 | Geode Capital Management, LLC | 5.05M (2.32%) | 1.48K Increased by +0.03% | Dec 31, 25 |
| 12 | Two Sigma Investments LLC | 4.52M (2.07%) | 95.69K Increased by +2.12% | Dec 31, 25 |
| 13 | venBio Select Advisor LLC | 4.50M (2.06%) | -4.20M Decreased by -93.33% | Jun 30, 25 |
| 14 | D. E. Shaw & Co LP | 4.39M (2.01%) | 2.80M Increased by +63.80% | Jun 30, 25 |
| 15 | Arrowstreet Capital Limited Partnership | 4.28M (1.96%) | 4.08M Increased by +95.46% | Jun 30, 25 |
| 16 | Pictet Asset Manangement SA | 4.19M (1.92%) | 4.19M Increased by +100.00% | Sep 30, 23 |
| 17 | Two Sigma Advisers, LLC | 4.09M (1.87%) | -151.60K Decreased by -3.71% | Dec 31, 25 |
| 18 | RP Management, LLC | 3.85M (1.76%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 19 | Millennium Management LLC | 3.81M (1.75%) | 3.02M Increased by +79.28% | Mar 31, 25 |
| 20 | Assenagon Asset Management SA | 3.62M (1.66%) | 3.61M Increased by +99.61% | Jun 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | BioPharma Credit Ord | 17.22M (7.89%) | 17.22M Increased by +100.00% | Dec 31, 24 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 7.30M (3.35%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 3 | Vanguard US Total Market Shares ETF | 6.57M (3.01%) | -18.55K Decreased by -0.28% | Sep 30, 24 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 6.37M (2.92%) | 35.31K Increased by +0.55% | Feb 28, 26 |
| 5 | iShares Russell 2000 ETF | 5.72M (2.62%) | 1.74M Increased by +30.47% | Feb 28, 26 |
| 6 | SPDR® S&P Biotech ETF | 3.67M (1.68%) | 8.19K Increased by +0.22% | Aug 31, 25 |
| 7 | Pictet-Biotech P USD | 2.79M (1.28%) | -13.26K Decreased by -0.47% | Jul 31, 23 |
| 8 | ACAP Strategic A | 2.70M (1.24%) | -121.24K Decreased by -4.49% | Sep 30, 25 |
| 9 | Vanguard Small Cap Index | 2.63M (1.21%) | 5.57K Increased by +0.21% | Feb 28, 26 |
| 10 | Vanguard Institutional Extnd Mkt Idx Tr | 2.58M (1.18%) | 16.00K Increased by +0.62% | Feb 28, 26 |
| 11 | Fidelity® Select Biotechnology | 2.58M (1.18%) | -225.50K Decreased by -8.74% | Nov 30, 23 |
| 12 | Vanguard Strategic Equity Inv | 2.57M (1.18%) | 634.66K Increased by +24.69% | Dec 31, 25 |
| 13 | abrdn Healthcare Investors | 2.20M (1.01%) | 991.09K Increased by +45.10% | Feb 28, 26 |
| 14 | Fidelity Small Cap Index | 2.04M (0.94%) | -59.99K Decreased by -2.93% | Dec 31, 25 |
| 15 | Hood River Small-Cap Growth Instl | 1.99M (0.91%) | 1.32M Increased by +66.20% | Sep 30, 25 |
| 16 | Eventide Healthcare & Life Sciences I | 1.97M (0.90%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 17 | Fidelity® Small Cap Index | 1.82M (0.84%) | 49.54K Increased by +2.71% | Oct 31, 23 |
| 18 | Pictet-Global Megatrend Sel I USD | 1.75M (0.80%) | 438.00 Increased by +0.02% | Jul 31, 23 |
| 19 | iShares Russell 2000 Growth ETF | 1.75M (0.80%) | 412.51K Increased by +23.60% | Feb 28, 26 |
| 20 | iShares Biotechnology ETF | 1.70M (0.78%) | 0.00 Increased by 0.00% | Feb 28, 26 |