| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Wellington Management Company LLP | 12.72M (15.28%) | 3.43M Increased by +26.97% | Dec 31, 25 |
| 2 | venBio Select Advisor LLC | 12.22M (14.68%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 3 | EcoR1 Capital, LLC | 11.90M (14.29%) | 0.00 Increased by 0.00% | Jun 30, 25 |
| 4 | Vanguard Group Inc | 10.67M (12.82%) | 687.47K Increased by +6.44% | Dec 31, 25 |
| 5 | Morgan Stanley - Brokerage Accounts | 9.64M (11.58%) | -108.95K Decreased by -1.13% | Sep 30, 25 |
| 6 | JPMorgan Chase & Co | 7.77M (9.33%) | 1.41M Increased by +18.21% | Sep 30, 24 |
| 7 | Deep Track Capital, LP | 7.75M (9.31%) | -250.38K Decreased by -3.23% | Dec 31, 25 |
| 8 | RTW INVESTMENTS, LLC | 7.67M (9.21%) | 7.67M Increased by +100.00% | Dec 31, 25 |
| 9 | BlackRock Inc | 6.27M (7.53%) | -136.53K Decreased by -2.18% | Sep 30, 25 |
| 10 | Suvretta Capital Management, LLC | 4.14M (4.97%) | 1.26M Increased by +30.47% | Dec 31, 25 |
| 11 | State Street Corp | 4.04M (4.85%) | 474.92K Increased by +11.76% | Sep 30, 25 |
| 12 | Polar Capital Holdings PLC | 3.71M (4.45%) | 1.06M Increased by +28.50% | Dec 31, 25 |
| 13 | UBS Group AG | 3.43M (4.12%) | -1.31M Decreased by -38.06% | Sep 30, 25 |
| 14 | T. Rowe Price Investment Management,Inc. | 2.99M (3.59%) | -1.06M Decreased by -35.61% | Sep 30, 24 |
| 15 | State Street Corporation | 2.91M (3.50%) | -5.89K Decreased by -0.20% | Mar 31, 24 |
| 16 | Marshall Wace Asset Management Ltd | 2.70M (3.25%) | 2.68M Increased by +99.13% | Jun 30, 25 |
| 17 | Siren, L.L.C. | 2.58M (3.10%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 18 | Orbimed Advisors, LLC | 2.43M (2.92%) | 106.50K Increased by +4.38% | Dec 31, 25 |
| 19 | AQR Capital Management LLC | 2.28M (2.73%) | -2.21M Decreased by -97.10% | Dec 31, 25 |
| 20 | Assenagon Asset Management SA | 2.14M (2.58%) | 1.41M Increased by +65.74% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 8.15M (9.79%) | 1.82M Increased by +22.34% | Dec 31, 25 |
| 2 | iShares Core S&P Small-Cap ETF | 6.21M (7.46%) | 6.21M Increased by +100.00% | Feb 28, 26 |
| 3 | Polar Capital Biotech S Inc | 3.75M (4.50%) | 3.75M Increased by +100.00% | Jan 31, 26 |
| 4 | Vanguard Total Stock Mkt Idx Inv | 3.40M (4.09%) | 7.38K Increased by +0.22% | Feb 28, 26 |
| 5 | Vanguard US Total Market Shares ETF | 3.30M (3.97%) | 2.68K Increased by +0.08% | Sep 30, 24 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 2.87M (3.45%) | 15.82K Increased by +0.55% | Feb 28, 26 |
| 7 | Vanguard Small Cap Index | 2.44M (2.93%) | 5.14K Increased by +0.21% | Feb 28, 26 |
| 8 | US Small-Cap Growth II Equity Comp | 1.79M (2.15%) | 1.79M Increased by +100.00% | Jun 30, 23 |
| 9 | SPDR® S&P Biotech ETF | 1.76M (2.11%) | 3.92K Increased by +0.22% | Aug 31, 25 |
| 10 | Vanguard Explorer Inv | 1.75M (2.10%) | 753.63K Increased by +43.08% | Dec 31, 25 |
| 11 | Worldwide Healthcare Ord | 1.51M (1.81%) | 0.00 Increased by 0.00% | Nov 30, 25 |
| 12 | Vanguard Small Cap Growth Index Inv | 1.36M (1.63%) | 3.76K Increased by +0.28% | Feb 28, 26 |
| 13 | DWS Vermögensbildungsfonds I LD | 1.32M (1.59%) | 1.32M Increased by +100.00% | Jan 31, 26 |
| 14 | JPM US Mid Cap Growth-Composite | 1.30M (1.56%) | 294.66K Increased by +22.62% | Sep 30, 24 |
| 15 | JPMorgan Mid Cap Growth I | 1.30M (1.56%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 16 | T. Rowe Price Health Sciences | 1.29M (1.55%) | -29.49K Decreased by -2.28% | Mar 31, 24 |
| 17 | Fidelity® Select Biotechnology | 1.28M (1.54%) | 56.40K Increased by +4.41% | Nov 30, 23 |
| 18 | T. Rowe Price US Mid-Cap Growth Equity | 1.20M (1.44%) | -145.16K Decreased by -12.13% | Sep 30, 24 |
| 19 | Vanguard Institutional Extnd Mkt Idx Tr | 1.12M (1.34%) | 8.45K Increased by +0.76% | Feb 28, 26 |
| 20 | T. Rowe Price Small-Cap Stock | 1.09M (1.30%) | -1.60K Decreased by -0.15% | Dec 31, 23 |