| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | EcoR1 Capital, LLC | 7.88M (45.66%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 2 | Point72 Asset Management, L.P. | 1.93M (11.20%) | -332.64K Decreased by -17.21% | Dec 31, 25 |
| 3 | FMR Inc | 1.91M (11.04%) | -1.13M Decreased by -59.05% | Mar 31, 25 |
| 4 | Fidelity Management and Research Company | 1.91M (11.04%) | -1.13M Decreased by -59.05% | Mar 31, 25 |
| 5 | Fairmount Funds Management LLC | 1.82M (10.52%) | 1.82M Increased by +100.00% | Dec 31, 24 |
| 6 | BlackRock Inc | 1.72M (9.98%) | -64.61K Decreased by -3.75% | Sep 30, 25 |
| 7 | Morgan Stanley - Brokerage Accounts | 1.56M (9.02%) | -313.58K Decreased by -20.15% | Sep 30, 25 |
| 8 | Vanguard Group Inc | 1.54M (8.95%) | 67.05K Increased by +4.34% | Dec 31, 25 |
| 9 | TANG CAPITAL MANAGEMENT LLC | 1.33M (7.72%) | -1.55K Decreased by -0.12% | Dec 31, 25 |
| 10 | Boxer Capital LLC | 1.30M (7.53%) | 0.00 Increased by 0.00% | Sep 30, 24 |
| 11 | Boxer Capital Management, LLC | 1.30M (7.53%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 12 | UBS Group AG | 1.27M (7.37%) | 782.23K Increased by +61.47% | Jun 30, 25 |
| 13 | State Street Corporation | 1.21M (7.00%) | 763.06K Increased by +63.20% | Mar 31, 24 |
| 14 | Bank of America Corp | 1.08M (6.24%) | -67.16K Decreased by -6.24% | Jun 30, 25 |
| 15 | BRAIDWELL LP | 1.05M (6.08%) | -104.60K Decreased by -9.96% | Sep 30, 23 |
| 16 | Citigroup Inc | 1.05M (6.06%) | -24.76K Decreased by -2.37% | Jun 30, 25 |
| 17 | Sofinnova Ventures | 1.03M (5.98%) | -127.67K Decreased by -12.37% | Jun 30, 25 |
| 18 | Great Point Partners LLC | 976.98K (5.66%) | 0.00 Increased by 0.00% | Mar 31, 24 |
| 19 | State Street Corp | 873.43K (5.06%) | 52.40K Increased by +6.00% | Sep 30, 25 |
| 20 | Sanofi | 821.92K (4.76%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard US Total Market Shares ETF | 733.95K (4.25%) | 129.10K Increased by +17.59% | Sep 30, 24 |
| 2 | Fidelity Small Cap Growth | 625.15K (3.62%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 614.55K (3.56%) | 0.00 Increased by 0.00% | Feb 28, 26 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 587.71K (3.41%) | 3.26K Increased by +0.56% | Feb 28, 26 |
| 5 | Eventide Healthcare & Life Sciences I | 568.32K (3.29%) | 141.32K Increased by +24.87% | Jun 30, 24 |
| 6 | FIAM Small Cap Core Composite | 460.10K (2.67%) | -11.00K Decreased by -2.39% | Mar 31, 25 |
| 7 | iShares Russell 2000 ETF | 448.28K (2.60%) | 30.58K Increased by +6.82% | Feb 28, 26 |
| 8 | US Small-Cap Growth II Equity Comp | 440.07K (2.55%) | -105.21K Decreased by -23.91% | Jun 30, 25 |
| 9 | T. Rowe Price New Horizons | 371.08K (2.15%) | -68.99K Decreased by -18.59% | Jul 31, 25 |
| 10 | T. Rowe Price Health Sciences | 367.82K (2.13%) | 74.18K Increased by +20.17% | Sep 30, 24 |
| 11 | Fidelity Select Biotechnology | 341.57K (1.98%) | 66.10K Increased by +19.35% | Sep 30, 24 |
| 12 | FIAM Small Cap Core CIT Cl B | 341.50K (1.98%) | -118.60K Decreased by -34.73% | Apr 30, 25 |
| 13 | SPDR® S&P Biotech ETF | 326.85K (1.89%) | 730.00 Increased by +0.22% | Aug 31, 25 |
| 14 | Fidelity Stock Selector Small Cap | 317.17K (1.84%) | 15.50K Increased by +4.89% | Jan 31, 25 |
| 15 | Federated Hermes Kaufmann Small Cap A | 290.00K (1.68%) | 104.93K Increased by +36.18% | Dec 31, 25 |
| 16 | Federated Hermes Kaufmann Small Cap Grow | 290.00K (1.68%) | 104.93K Increased by +36.18% | Dec 31, 25 |
| 17 | Fidelity Small Cap Growth K6 | 280.31K (1.62%) | 1.42K Increased by +0.51% | Mar 31, 25 |
| 18 | Fidelity Series Small Cap Opps | 269.44K (1.56%) | 0.00 Increased by 0.00% | Jan 31, 25 |
| 19 | Nuveen Quant Small Cap Equity R6 | 269.06K (1.56%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 20 | Vanguard Small Cap Index | 268.97K (1.56%) | 231.00 Increased by +0.09% | Feb 28, 25 |