| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Group Inc | 5.59M (11.24%) | -10.52K Decreased by -0.19% | Dec 31, 25 |
| 2 | Wellington Management Company LLP | 5.20M (10.44%) | -666.57K Decreased by -12.82% | Sep 30, 23 |
| 3 | Farallon Capital Management, L.L.C. | 5.16M (10.36%) | -621.56K Decreased by -12.05% | Dec 31, 25 |
| 4 | BlackRock Inc | 4.55M (9.13%) | -288.02K Decreased by -6.34% | Sep 30, 25 |
| 5 | Bellevue Group AG | 3.59M (7.21%) | 75.00K Increased by +2.09% | Jun 30, 25 |
| 6 | State Street Corporation | 3.14M (6.30%) | 512.51K Increased by +16.33% | Mar 31, 24 |
| 7 | Armistice Capital, LLC | 3.04M (6.10%) | 2.27M Increased by +74.84% | Dec 31, 25 |
| 8 | Erste Asset Management GmbH | 2.80M (5.63%) | 40.00K Increased by +1.43% | Dec 31, 25 |
| 9 | COMMODORE CAPITAL LP | 2.34M (4.70%) | 13.29K Increased by +0.57% | Sep 30, 25 |
| 10 | State Street Corp | 2.26M (4.54%) | 311.60K Increased by +13.77% | Sep 30, 25 |
| 11 | Macquarie Group Ltd | 1.96M (3.93%) | 57.51K Increased by +2.94% | Sep 30, 25 |
| 12 | D. E. Shaw & Co LP | 1.84M (3.69%) | 1.47M Increased by +79.98% | Dec 31, 25 |
| 13 | First Trust Advisors L.P. | 1.82M (3.65%) | 43.48K Increased by +2.39% | Dec 31, 23 |
| 14 | T. Rowe Price Associates, Inc. | 1.66M (3.33%) | -617.31K Decreased by -37.26% | Sep 30, 25 |
| 15 | Jefferies Financial Group Inc | 1.50M (3.01%) | 1.50M Increased by +100.00% | Dec 31, 24 |
| 16 | Geode Capital Management, LLC | 1.41M (2.84%) | -2.78K Decreased by -0.20% | Dec 31, 25 |
| 17 | Citadel Advisors Llc | 1.35M (2.71%) | 856.99K Increased by +63.53% | Dec 31, 25 |
| 18 | MPM Oncology Impact Management LP | 1.30M (2.62%) | 1.30M Increased by +100.00% | Dec 31, 25 |
| 19 | Frazier Life Sciences Management, L.P. | 1.28M (2.57%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 20 | Marshall Wace Asset Management Ltd | 1.26M (2.54%) | 129.55K Increased by +10.26% | Sep 30, 24 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | Vanguard Health Care Inv | 5.15M (10.34%) | 0.00 Increased by 0.00% | Sep 30, 23 |
| 2 | BB Biotech AG Ord | 3.71M (7.46%) | 124.59K Increased by +3.35% | Sep 30, 25 |
| 3 | Vanguard Total Stock Mkt Idx Inv | 1.86M (3.73%) | 7.04K Increased by +0.38% | Feb 28, 26 |
| 4 | State Street® SPDR® S&P® Biotech ETF | 1.80M (3.62%) | 9.93K Increased by +0.55% | Feb 28, 26 |
| 5 | Vanguard US Total Market Shares ETF | 1.79M (3.59%) | 2.35K Increased by +0.13% | Sep 30, 24 |
| 6 | First Trust NYSE Arca Biotech ETF | 1.76M (3.54%) | -143.00 Decreased by -0.01% | Dec 28, 23 |
| 7 | Delaware US Small Cap Core Equity (SMA) | 1.61M (3.24%) | -18.86K Decreased by -1.17% | Mar 31, 24 |
| 8 | Macquarie US Small Cap Core Equity | 1.61M (3.24%) | -18.86K Decreased by -1.17% | Mar 31, 24 |
| 9 | Macquarie Small Cap Core I | 1.43M (2.87%) | -107.41K Decreased by -7.51% | Jul 31, 25 |
| 10 | Delaware Small Cap Core I | 1.38M (2.77%) | 0.00 Increased by 0.00% | Oct 31, 24 |
| 11 | iShares Russell 2000 ETF | 1.37M (2.75%) | 196.48K Increased by +14.34% | Feb 28, 26 |
| 12 | Vanguard Small Cap Index | 1.32M (2.66%) | 2.81K Increased by +0.21% | Feb 28, 26 |
| 13 | Nomura Small Cap Core I | 1.25M (2.51%) | -157.65K Decreased by -12.63% | Jan 31, 26 |
| 14 | Polar Capital Biotech S Inc | 1.00M (2.01%) | 0.00 Increased by 0.00% | Mar 31, 25 |
| 15 | DWS Vermögensbildungsfonds I LD | 805.52K (1.62%) | 3.00 Increased by +0.00% | Jul 31, 25 |
| 16 | Vanguard Small Cap Growth Index Inv | 734.16K (1.47%) | -396.00 Decreased by -0.05% | Feb 28, 26 |
| 17 | BNP Paribas US Small Cap ClassicC | 733.31K (1.47%) | 646.88K Increased by +88.21% | Jan 31, 26 |
| 18 | American Funds SMALLCAP World A | 703.87K (1.41%) | 703.87K Increased by +100.00% | Dec 31, 25 |
| 19 | Vanguard Institutional Extnd Mkt Idx Tr | 639.41K (1.28%) | 3.81K Increased by +0.60% | Feb 28, 26 |
| 20 | SPDR® S&P Biotech ETF | 601.90K (1.21%) | 1.34K Increased by +0.22% | Aug 31, 25 |