| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management,Inc. | 16.21M (38.37%) | 9.86M Increased by +60.82% | Dec 31, 25 |
| 2 | Paradigm Biocapital Advisors LP | 5.72M (13.55%) | 1.07M Increased by +18.78% | Dec 31, 25 |
| 3 | Vanguard Group Inc | 4.08M (9.66%) | 174.43K Increased by +4.27% | Dec 31, 25 |
| 4 | FMR Inc | 3.56M (8.43%) | -2.20M Decreased by -61.67% | Dec 31, 25 |
| 5 | BlackRock Inc | 3.39M (8.02%) | -80.29K Decreased by -2.37% | Sep 30, 25 |
| 6 | NEA Management Company, LLC | 3.05M (7.21%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 7 | Vestal Point Capital LP | 2.92M (6.92%) | 1.68M Increased by +57.26% | Dec 31, 25 |
| 8 | Perceptive Advisors LLC | 2.47M (5.84%) | -9.65K Decreased by -0.39% | Sep 30, 25 |
| 9 | SR ONE CAPITAL MANAGEMENT, LP | 2.35M (5.55%) | 0.00 Increased by 0.00% | Dec 31, 25 |
| 10 | State Street Corporation | 1.77M (4.20%) | -240.41K Decreased by -13.55% | Dec 31, 23 |
| 11 | JPMorgan Chase & Co | 1.77M (4.18%) | 788.04K Increased by +44.65% | Sep 30, 25 |
| 12 | State Street Corp | 1.53M (3.61%) | -66.29K Decreased by -4.34% | Sep 30, 25 |
| 13 | Citadel Advisors Llc | 1.50M (3.55%) | 478.77K Increased by +31.91% | Dec 31, 25 |
| 14 | RA Capital Management, LLC | 1.27M (3.00%) | -1.77M Decreased by -139.63% | Dec 31, 25 |
| 15 | T. Rowe Price Associates, Inc. | 1.26M (2.99%) | -174.72K Decreased by -13.82% | Sep 30, 25 |
| 16 | Novo A/S | 1.07M (2.54%) | 75.00K Increased by +6.98% | Sep 30, 23 |
| 17 | AJU IB Investment Co Ltd | 1.05M (2.48%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| 18 | HHG PLC | 1.01M (2.40%) | -9.66K Decreased by -0.95% | Sep 30, 25 |
| 19 | Geode Capital Management, LLC | 958.06K (2.27%) | 31.75K Increased by +3.31% | Dec 31, 25 |
| 20 | Capital World Investors | 783.01K (1.85%) | 0.00 Increased by 0.00% | Sep 30, 25 |
| Rank | Holder | SharesFloat % | Change | Date reported |
|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation | 2.76M (6.53%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 2 | Vanguard Total Stock Mkt Idx Inv | 1.87M (4.42%) | 4.06K Increased by +0.22% | Feb 28, 26 |
| 3 | T. Rowe Price US Mid-Cap Growth Equity | 1.21M (2.86%) | 428.90K Increased by +35.50% | Dec 31, 25 |
| 4 | T. Rowe Price Mid-Cap Growth | 1.21M (2.86%) | -1.00K Decreased by -0.08% | Jan 31, 26 |
| 5 | Fidelity® Select Biotechnology | 1.19M (2.82%) | -167.40K Decreased by -14.04% | Nov 30, 23 |
| 6 | State Street® SPDR® S&P® Biotech ETF | 1.16M (2.76%) | 6.41K Increased by +0.55% | Feb 28, 26 |
| 7 | T. Rowe Price US Small-Cap Core Equity | 917.84K (2.17%) | 200.31K Increased by +21.82% | Dec 31, 25 |
| 8 | T. Rowe Price Small-Cap Stock | 916.45K (2.17%) | -1.39K Decreased by -0.15% | Jan 31, 26 |
| 9 | iShares Russell 2000 ETF | 827.67K (1.96%) | 619.03K Increased by +74.79% | Feb 28, 26 |
| 10 | American Funds SMALLCAP World A | 783.01K (1.85%) | 73.64K Increased by +9.40% | Jun 30, 25 |
| 11 | SPDR® S&P Biotech ETF | 688.11K (1.63%) | 1.53K Increased by +0.22% | Aug 31, 25 |
| 12 | T. Rowe Price Small-Cap Value | 682.86K (1.62%) | -935.00 Decreased by -0.14% | Jan 31, 26 |
| 13 | Vanguard Small Cap Index | 656.21K (1.55%) | 1.38K Increased by +0.21% | Feb 28, 26 |
| 14 | JPMorgan Mid Cap Growth I | 624.34K (1.48%) | 174.09K Increased by +27.88% | Jan 31, 26 |
| 15 | T. Rowe Price Health Sciences | 603.34K (1.43%) | 221.35K Increased by +36.69% | Jan 31, 26 |
| 16 | Fidelity Growth Compy Commingled Pl S | 596.40K (1.41%) | -360.84K Decreased by -60.50% | Dec 31, 25 |
| 17 | JNL/T. Rowe Price Capital Appreciation A | 584.23K (1.38%) | 303.13K Increased by +51.89% | Dec 31, 25 |
| 18 | Fidelity Growth Company Fund | 536.04K (1.27%) | -219.03K Decreased by -40.86% | Dec 31, 25 |
| 19 | T. Rowe Price Instl Small-Cap Stock | 496.38K (1.17%) | 0.00 Increased by 0.00% | Jan 31, 26 |
| 20 | Janus Henderson Global Life Sciences D | 484.24K (1.15%) | -6.26K Decreased by -1.29% | Sep 30, 24 |